Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Determination of Crystal Structures01:29

Determination of Crystal Structures

24
In the late 1800s, the revelation that light extended beyond visible wavelengths led to the discovery of X-rays by Wilhelm Roentgen. Recognized as high-energy electromagnetic radiation with short wavelengths, X-rays prompted exploration into their interaction with crystals. Max von Laue proposed in 1912 that the periodic arrangement of atoms, ions, or molecules in crystals would cause them to diffract X-rays, a hypothesis confirmed through experiments with copper sulfate and zinc sulfide...
24
Crystal Growth: Principles of Crystallization01:25

Crystal Growth: Principles of Crystallization

5.5K
Crystallization is a phase transformation process in which crystals are precipitated from a supersaturated solution or formed from other sources. During crystallization, atoms or molecules arrange themselves into a well-defined, rigid crystal lattice to minimize energy.
Initiating crystallization involves manipulating the concentration of the solute and the temperature of the solution. Since crystal growth occurs when the ratio of concentration and solubility of the solute in the solvent...
5.5K
Imperfections in Crystal Structure: Stoichiometric Point Defects01:26

Imperfections in Crystal Structure: Stoichiometric Point Defects

30
Schottky defects arise when some lattice points in a crystal, such as those in NaCl, remain unoccupied, creating lattice vacancies without disturbing the overall electrical neutrality of the crystal. This defect is common in ionic crystals where the positive and negative ions are similar in size, as seen in sodium chloride and cesium chloride. The presence of Schottky defects enables the crystal to conduct electricity to a small extent through an ionic mechanism. Electric fields cause nearby...
30
Imperfections in Crystal Structure: Point, Line and Plane Defects01:25

Imperfections in Crystal Structure: Point, Line and Plane Defects

24
A perfect crystal, in theory, has a uniform structure with the same unit cell and lattice points throughout. However, any deviation from this periodic arrangement is known as an imperfection or defect. These defects can be categorized into three types: point, line, and plane defects.Point defects occur when there is a deviation from the ideal due to missing atoms, displaced atoms, or additional atoms. These imperfections might occur due to imperfect packing during crystallization or because of...
24
X-ray Crystallography02:18

X-ray Crystallography

26.6K
The size of the unit cell and the arrangement of atoms in a crystal may be determined from measurements of the diffraction of X-rays by the crystal, termed X-ray crystallography.
Diffraction
Diffraction is the change in the direction of travel experienced by an electromagnetic wave when it encounters a physical barrier whose dimensions are comparable to those of the wavelength of the light. X-rays are electromagnetic radiation with wavelengths about as long as the distance between neighboring...
26.6K
Imperfections in Crystal Structure: Non-Stoichiometric Defects01:29

Imperfections in Crystal Structure: Non-Stoichiometric Defects

20
Non-stoichiometric defects refer to a type of defect in the crystal structure of a compound where the ratio of its constituent elements deviates from the ideal stoichiometric ratio. There are two main types of non-stoichiometric defects: metal excess defects and metal deficiency defects.Metal excess defects occur when there is a slight surplus of metal ions than what is required by the stoichiometric ratio of the compound. For example, heating a sodium chloride crystal in sodium vapor results...
20

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Access to Care and Patient Safety Measures: Placement in Healthcare Quality Frameworks, Degree to Which They Meet Criteria Used to Select and/or Prioritize Quality Measures, and Mapping to the National Quality Strategy levers.

American journal of medical quality : the official journal of the American College of Medical Quality·2026
Same author

Adult Misuse of ADHD Stimulant Medication in the United States: A Rapid Review.

Journal of clinical psychopharmacology·2026
Same author

Criteria to Prioritize Measures of Healthcare Quality: A Scoping Review.

Journal for healthcare quality : official publication of the National Association for Healthcare Quality·2026
Same author

Frameworks for Health Care Quality and Disparities in Health Care Quality: A Scoping Review.

Journal for healthcare quality : official publication of the National Association for Healthcare Quality·2026
Same author

Care of Bereaved Persons : A Systematic Review.

Annals of internal medicine·2026
Same author

Initiatives to Support the Homelife of Women Physicians: A Systematic Review.

Journal of general internal medicine·2025

Related Experiment Video

Updated: Mar 8, 2026

Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes
11:42

Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes

Published on: November 1, 2012

10.4K

Designed DNA Crystal Habit Modifiers.

Diana Zhang1, Paul J Paukstelis1

  • 1Department of Chemistry & Biochemistry and Center for Biomolecular Structure and Organization, University of Maryland , College Park, Maryland 20742, United States.

Journal of the American Chemical Society
|January 18, 2017
PubMed
Summary
This summary is machine-generated.

Researchers can now control the shape of 3D DNA crystals using "poison" oligonucleotides. This breakthrough in DNA nanotechnology allows for tailored crystal habits for advanced applications.

More Related Videos

Optimization of Crystal Growth for Neutron Macromolecular Crystallography
12:29

Optimization of Crystal Growth for Neutron Macromolecular Crystallography

Published on: March 13, 2021

6.0K
On-Chip Crystallization and Large-Scale Serial Diffraction at Room Temperature
07:42

On-Chip Crystallization and Large-Scale Serial Diffraction at Room Temperature

Published on: March 11, 2022

2.4K

Related Experiment Videos

Last Updated: Mar 8, 2026

Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes
11:42

Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes

Published on: November 1, 2012

10.4K
Optimization of Crystal Growth for Neutron Macromolecular Crystallography
12:29

Optimization of Crystal Growth for Neutron Macromolecular Crystallography

Published on: March 13, 2021

6.0K
On-Chip Crystallization and Large-Scale Serial Diffraction at Room Temperature
07:42

On-Chip Crystallization and Large-Scale Serial Diffraction at Room Temperature

Published on: March 11, 2022

2.4K

Area of Science:

  • DNA nanotechnology
  • Materials science
  • Nanoscale self-assembly

Background:

  • DNA is a versatile molecule for creating nanoscale structures.
  • A key goal is assembling macroscopic 3D DNA crystals for precise molecule positioning.
  • Tailoring crystal properties, like morphology, is crucial for integration into complex systems.

Purpose of the Study:

  • To demonstrate control over the crystal habits of 3D DNA crystals.
  • To investigate the use of modified DNA sequences to alter crystal morphology.
  • To enable the integration of DNA crystals into more complex systems.

Main Methods:

  • Self-assembly of a 3D DNA crystal using a DNA 13-mer.
  • Introduction of "poison" oligonucleotides to disrupt specific base-pairing interactions.
  • Application of poison oligonucleotides during initial crystallization and shell layer growth.

Main Results:

  • Predictable modification of 3D DNA crystal habits was achieved.
  • Poison oligonucleotides effectively altered crystal morphology.
  • Habit modification was successful both during initial crystal formation and subsequent growth phases.

Conclusions:

  • Crystal habits of 3D DNA crystals can be predictably altered using poison oligonucleotides.
  • This method allows for tailored DNA crystal morphologies for diverse applications.
  • The technique is applicable during both primary crystallization and secondary growth stages.