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Systemic Metabolite Changes in Wild-type C57BL/6 Mice Fed Black Raspberries
Pan Pan1, Chad W Skaer1, Hsin-Tzu Wang1
1a Department of Medicine , Division of Hematology and Oncology, Medical College of Wisconsin , Milwaukee , Wisconsin , USA.
Nutrition and Cancer
|January 18, 2017
Summary
Black raspberries (BRBs) alter metabolites in the colon, liver, and gut. These findings support BRBs as a chemopreventive agent and beneficial dietary supplement for colorectal cancer prevention.
Area of Science:
- Nutritional metabolomics
- Cancer chemoprevention
- Dietary interventions
Background:
- Freeze-dried black raspberries (BRBs) show chemopreventive effects against colorectal cancer.
- Understanding BRB-induced metabolic changes is crucial for elucidating their health benefits.
Purpose of the Study:
- To investigate metabolite alterations in response to BRB consumption.
- To identify potential biomarkers of BRB intake.
Main Methods:
- Wild-type C57BL/6 mice were fed control or 5% BRB-supplemented diets for 8 weeks.
- Nontargeted metabolomic analysis was performed on colonic mucosa, liver, and fecal samples.
Main Results:
- BRBs significantly altered metabolite levels across all analyzed tissues (41 in colon, 40 in liver, 34 in feces).
- Specific changes included reduced lipids in colonic mucosa and increased amino acids in the liver.
- Elevated omega-3 polyunsaturated fatty acids (ω-3 PUFAs) were observed in the liver; 3-[3-(sulfooxy) phenyl] propanoic acid may serve as a biomarker.
Conclusions:
- BRBs induce systemic metabolic changes, supporting their role in chemoprevention.
- These findings highlight BRBs as a potentially beneficial dietary supplement for health.
