Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Brain Imaging01:14

Brain Imaging

835
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
835

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The interaction of age and total lifetime drinks is associated with regional cortical perfusion and thickness in healthy adults with low-level alcohol consumption.

Alcohol (Fayetteville, N.Y.)·2026
Same author

Low level alcohol consumption is associated with lower regional brain volume and thickness and lower choline-containing compounds and myo-inositol levels in healthy adults.

Alcohol (Fayetteville, N.Y.)·2025
Same author

Kynurenine Metabolism is Associated with Antidepressant Response to Selective Serotonin Reuptake Inhibitors.

bioRxiv : the preprint server for biology·2025
Same author

Pro-atherogenic medical conditions are associated with widespread regional brain metabolite abnormalities in those with alcohol use disorder.

Alcohol and alcoholism (Oxford, Oxfordshire)·2024
Same author

Frontal Brain N-Acetylaspartate at Treatment Entry is Related to Future World Health Organization Risk Drinking Levels in Individuals With Alcohol Use Disorder.

Journal of studies on alcohol and drugs·2024
Same author

Multi-modal neuroimaging reveals differences in alcohol-cue reactivity but not neurometabolite concentrations in adolescents who drink alcohol.

Drug and alcohol dependence·2024

Related Experiment Video

Updated: Mar 8, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

8.0K

Structural Neuroimaging in Polysubstance Users.

Dieter J Meyerhoff1

  • 1Department of Radiology and Biomedical Imaging, University of California San Francisco, and Veterans Administration Medical Center, San Francisco, CA 94121, USA.

Current Opinion in Behavioral Sciences
|January 18, 2017
PubMed
Summary

Polysubstance use (PSU) alters brain structure differently than single-substance use, with subcortical enlargements potentially masking cortical atrophy. More research is needed to understand these complex brain changes for better treatment.

More Related Videos

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

4.8K
Studying Metabolic Brain Connectivity Using 2-Deoxy-2-[18F]Fluoro-D-Glucose Dynamic Positron Emission Tomography at the Single-subject Level
07:28

Studying Metabolic Brain Connectivity Using 2-Deoxy-2-[18F]Fluoro-D-Glucose Dynamic Positron Emission Tomography at the Single-subject Level

Published on: January 24, 2025

751

Related Experiment Videos

Last Updated: Mar 8, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

8.0K
Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

4.8K
Studying Metabolic Brain Connectivity Using 2-Deoxy-2-[18F]Fluoro-D-Glucose Dynamic Positron Emission Tomography at the Single-subject Level
07:28

Studying Metabolic Brain Connectivity Using 2-Deoxy-2-[18F]Fluoro-D-Glucose Dynamic Positron Emission Tomography at the Single-subject Level

Published on: January 24, 2025

751

Area of Science:

  • Neuroimaging
  • Addiction Medicine
  • Neuroscience

Background:

  • Polysubstance use (PSU), the concurrent use of multiple substances, is increasingly prevalent.
  • Previous research primarily focused on monosubstance use, yielding insights into substance-specific brain alterations.
  • Limited data exist on the neurobiological impact of PSU on brain morphometry.

Purpose of the Study:

  • To investigate the unique effects of polysubstance use on brain structure.
  • To compare morphometric alterations in PSU individuals with those reported for monosubstance users.
  • To highlight the need for advanced neuroimaging methods to study PSU's complex brain effects.

Main Methods:

  • Structural magnetic resonance imaging (MRI) was employed to assess brain morphometry.
  • Analysis focused on regional gray matter and white matter changes.
  • Comparison of findings with existing literature on monosubstance use.

Main Results:

  • Polysubstance use is associated with morphometric alterations distinct from additive effects of individual substances.
  • Observed subcortical volume enlargements may mask underlying cortical atrophy.
  • Brain changes in PSU individuals are not simply a sum of monosubstance effects.

Conclusions:

  • Polysubstance use induces complex, non-additive changes in brain structure.
  • Current understanding of substance-related brain alterations may underestimate cortical atrophy in PSU.
  • Further rigorous neuroimaging studies are crucial for developing effective treatments for polysubstance users.