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Published on: May 9, 2025
Pre-exposure prophylaxis and antiretroviral treatment interventions with drug resistance
Komi Afassinou1, Faraimunashe Chirove2, Keshlan S Govinder2
1School of Mathematics, Statistics and Computer Science, University of KwaZulu-Natal, South Africa; DST-NRF Center of Excellence in Mathematical and Statistical Sciences (CoE-MaSS), South Africa.
Abstract:
We introduce a model for HIV/AIDS which can be utilized to assess the impact of combining pre-exposure prophylaxis (PrEP) and antiretroviral drugs (ARVs) use interventions (incorporating drug resistance). Mathematical and numerical analyses are carried out to investigate the effects of the combined controls in the presence of PrEP drug resistance. Our results predict a significant decrease in the number of new HIV infections when PrEP and ARVs are concurrently implemented at high levels. The results also reveal that PrEP drug resistance has the potential to slow down or reverse the effects of PrEP, especially at low efficacy levels.
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