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The Use of MitraClip for Symptomatic Patients with Hypertrophic Obstructive Cardiomyopathy

Felix Thomas1, Florian Rader, Robert J Siegel

  • 1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Cardiology
|January 18, 2017
PubMed

Insights

The MitraClip device offers a safe and effective treatment for hypertrophic obstructive cardiomyopathy (HOCM), reducing left-ventricular outflow tract gradients and improving symptoms without causing conduction abnormalities.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Medical Devices

Background:

  • Symptomatic hypertrophic obstructive cardiomyopathy (HOCM) presents treatment challenges.
  • Current therapies like septal myectomy and alcohol septal ablation (ASA) carry risks of cardiac conduction abnormalities.
  • The MitraClip system presents a novel, lower-risk alternative.

Purpose of the Study:

  • To review published data on the use of the MitraClip system for symptomatic HOCM patients.
  • To evaluate the safety and efficacy of MitraClip in treating HOCM with systolic anterior motion (SAM).

Main Methods:

  • A review of 4 studies involving 15 symptomatic HOCM patients treated with MitraClip.
  • Consolidation of data on mitral regurgitation (MR), left-ventricular outflow tract (LVOT) gradient, and NYHA class.

Main Results:

  • MitraClip resolved SAM in all patients.
  • Significant reduction in MR and LVOT gradient (mean 75.8 to 11.0 mm Hg).
  • Symptomatic improvement and no associated conduction abnormalities or arrhythmias.

Conclusions:

  • MitraClip therapy is a potentially safe and effective option for symptomatic HOCM.
  • It may help high-risk patients avoid risks associated with traditional therapies.
Abstract

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