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Updated: Mar 8, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
The burden of occupationally-related cutaneous malignant melanoma in Britain due to solar radiation
Lesley Rushton1, Sally J Hutchings1
1Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, Imperial College London, Norfolk Place, London W2 1PG, UK.
Background:
Increasing evidence highlights the association of occupational exposure and cutaneous malignant melanoma (CMM). We estimated the burden of CMM and total skin cancer burden in Britain due to occupational solar radiation exposure.
Methods:
Attributable fractions (AF) and numbers were estimated for CMM mortality and incidence using risk estimates from the published literature and national data sources for proportions exposed. We extended existing methods to account for the exposed population age structure.
Results:
The estimated total AF for CMM is 2.0% (95% CI: 1.4-2.7%), giving 48 (95% CI: 33-64) deaths in (2012) and 241 (95% CI: 168-325) registrations (in 2011) attributable to occupational exposure to solar radiation. Higher exposure and larger numbers exposed led to much higher numbers for men than women. Industries of concern are construction, agriculture, public administration and defence, and land transport.
Conclusions:
These results emphasise the urgent need to develop appropriate strategies to reduce this burden.
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