Related Experiment Video
Updated: Mar 8, 2026

Author Spotlight: Advancing Therapeutics to Treat Vibriosis in Humans and Aquatic Organisms
Published on: May 31, 2024
Antichlamydial Dimeric Indole Derivatives from Marine Actinomycete Rubrobacter radiotolerans
Jian Lin Li1, Dandan Chen1,2, Lei Huang1
1School of Pharmacy, Nantong University, Nantong, China.
Abstract:
Chlamydiae are widely distributed pathogens of human populations, which can lead to serious reproductive and other health problems. In our search for novel antichlamydial metabolites from marine derived-microorganisms, one new (1) and two known (2, 3) dimeric indole derivatives were isolated from the sponge-derived actinomycete Rubrobacter radiotolerans. The chemical structures of these metabolites were elucidated by NMR spectroscopic data as well as CD calculations. All three metabolites suppressed chlamydial growth in a concentration-dependent manner. Among them, compound 1 exhibited the most effective antichlamydial activity with IC50 values of 46.6 ~ 96.4 µM in the production of infectious progeny. Compounds appeared to target the mid-stage of the chlamydial developmental cycle by interfering with reticular body replication, but not directly inactivating the infectious elementary body.
More Related Videos
Related Concept Videos
Bacterial Phylum Actinobacteria
Bacterial Phylum Chlamydiae
Indirect-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
Reversible inhibitors display short to medium durations of action. Short-acting agents include simple alcohols with...
Gene Regulation in Microbial Communities: Quorum Sensing
Bacterial Phylum Spirochaetes
Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
The direct-acting...

