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ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection
Published on: February 10, 2017
The five-year survival rate after endoscopic submucosal dissection for superficial esophageal squamous cell neoplasia
Yasuaki Nagami1, Masaki Ominami1, Masatsugu Shiba1
1Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Background:
Endoscopic submucosal dissection (ESD) is a widely accepted procedure for superficial esophageal squamous cell neoplasia (ESCN) because of a high complete resection rate. However, there were a few reports about the long-term outcomes of these patients due to short follow-up periods.
Aims:
We aimed to evaluate the 5-year survival after ESD for superficial ESCN.
Methods:
This was a retrospective cohort study performed at a single institution. Between 2006 and 2009, 94 patients with superficial ESCN underwent ESD. Eighty-three patients (93.3%) who had completed an extended period of observation of at least 5 years were enrolled. The main outcomes were the 5-year survival rates. The secondary outcomes were the cumulative incidence rate of metachronous ESCN, and the clinical outcomes.
Results:
The 5-year relative overall survival rate was 99.0%, whereas the cause specific survival rate was 100% during 72.9 months of median follow up period. Subgroup analysis showed that the 5year survival of patients with EP/LPM and MM/SM1 (submucosal invasion ≤200μm) were 100% and 89.0%, respectively. The cumulative incidence rate of metachronous ESCN at 5 years was 16.8%.
Conclusion:
ESD for superficial ESCN is a curative treatment with a favorable 5-year survival rate.
