Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An antitumor principle from Suillus granulatus.

C Tringali1, C Geraci, G Nicolosi

  • 1Dipartimento di Scienze Chimiche, Catania, Italy.

Journal of Natural Products
|July 1, 1989
PubMed
Summary

Researchers identified suillin, an antitumor compound from Suillus granulatus mushroom. This compound demonstrated activity against P-388 leukemia in laboratory and animal studies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retraction Note: Silencing of membrane-associated sialidase Neu3 diminishes apoptosis resistance and triggers megakaryocytic differentiation of chronic myeloid leukemic cells K562 through the increase of ganglioside GM3.

Cell death and differentiation·2024
Same author

Cultivable fungal diversity in two karstic caves in Italy: under-investigated habitats as source of putative novel taxa.

Scientific reports·2024
Same author

FLT3-targeted therapy restores GATA1 pathway function in NPM1/FLT3-ITD mutated acute myeloid leukaemia.

EJHaem·2023
Same author

Venous thromboembolism in critically ill patients affected by ARDS related to COVID-19 in Northern-West Italy.

European review for medical and pharmacological sciences·2020
Same author

Signatures of de-domestication in autochthonous pig breeds and of domestication in wild boar populations from MC1R and NR6A1 allele distribution.

Animal genetics·2019
Same author

Design, synthesis and antibacterial evaluation of a polycationic calix[4]arene derivative alone and in combination with antibiotics.

MedChemComm·2018

Area of Science:

  • Natural Product Chemistry
  • Pharmacology
  • Oncology

Background:

  • Mushrooms are a source of bioactive compounds with therapeutic potential.
  • Suillus granulatus is a mushroom species with reported medicinal properties.
  • Leukemia remains a significant global health challenge requiring novel therapeutic agents.

Purpose of the Study:

  • To isolate and identify an antitumor compound from Suillus granulatus.
  • To evaluate the anticancer activity of the isolated compound against P-388 leukemia.
  • To determine the potential of suillin as a novel chemotherapeutic agent.

Main Methods:

  • Extraction and purification of compounds from Suillus granulatus.
  • In vitro assays to assess cytotoxicity against P-388 leukemia cells.
  • In vivo studies using a mouse model of P-388 leukemia.

Main Results:

  • Suillin was successfully isolated and identified from Suillus granulatus.
  • Suillin exhibited significant cytotoxic effects against P-388 leukemia cells in vitro.
  • Administration of suillin demonstrated antitumor activity in vivo against P-388 leukemia.

Conclusions:

  • Suillin is a novel antitumor compound isolated from Suillus granulatus.
  • Suillin possesses promising activity against P-388 leukemia, warranting further investigation.
  • This study highlights the potential of fungal natural products in cancer therapy.

Related Experiment Videos