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NIHR Clinical Research Networks: what they do and how they help paediatric research

Hanna Lythgoe1,2, Victoria Price1,2, Vanessa Poustie3

  • 1Department of Women's and Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

Archives of Disease in Childhood
|January 19, 2017
PubMed

Insights

The National Institute for Health Research (NIHR) Clinical Research Network (CRN): Children supports high-quality paediatric research delivery. It has successfully recruited over 200,000 participants to studies, improving research quality and accessibility.

Area of Science:

  • Paediatric Research
  • Health Services Research
  • Clinical Trials Management

Background:

  • The National Institute for Health Research (NIHR) Clinical Research Network (CRN): Children has a new structure within the NIHR infrastructure.
  • It supports the delivery of high-quality research in England's NHS.
  • The network provides resources and staff for research feasibility, site setup, patient recruitment, and study management.

Purpose of the Study:

  • To update paediatricians on the NIHR CRN: Children's structure and role.
  • To highlight the network's support for paediatric research delivery.
  • To emphasize the network's commitment to improving paediatric research.

Main Methods:

  • Review of the NIHR CRN: Children's operational structure and achievements.
  • Analysis of the network's portfolio, including interventional and randomised controlled studies.
  • Examination of participant recruitment data and public/patient involvement.

Main Results:

  • Over 80% of UK commercial contract studies were within the UKCRN Portfolio since 2013.
  • 33% of supported studies are interventional, with many being randomised controlled trials.
  • Over 200,000 participants recruited to Children's Portfolio studies, with approximately 500 studies currently open.

Conclusions:

  • The NIHR CRN: Children has successfully improved participant recruitment and public involvement in paediatric research.
  • Challenges in paediatric research persist, but the network is dedicated to continued support and improvement.
  • Education and engagement of paediatricians are crucial for enhancing the quality and delivery of paediatric research.

Keywords:
Child HealthClinical Research NetworksClinical TrialsNational Institute for Health ResearchPaediatrics

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