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Tuning Collective Cell Migration by Cell-Cell Junction Regulation.

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Cell-cell adhesion systems and their plasticity are crucial for collective cell migration. Junction dynamics dictate various cell movement types in different tissues.

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biophysics

Background:

  • Collective cell migration is fundamental for development and tissue repair.
  • Cell-cell adhesion molecules and the actin cytoskeleton are key regulators.
  • Diverse adhesion systems (cadherins, integrins, etc.) mediate cell interactions.

Purpose of the Study:

  • To review cell-cell adhesion systems involved in collective cell migration.
  • To highlight the role of junction plasticity in regulating migration dynamics.
  • To connect adhesion mechanisms to different collective cell movement types.

Main Methods:

  • Literature review of cell-cell adhesion systems and collective cell migration.
  • Analysis of molecular components and signaling pathways governing cell junctions.
  • Categorization of collective cell movement based on junction plasticity.

Main Results:

  • Multiple adhesion receptor systems (cadherins, Ig superfamily, Eph/Ephrin, Slit/Robo, connexins, integrins) are implicated.
  • Cell-cell junction plasticity, influenced by molecular composition and signaling, enables diverse migration patterns.
  • Junction plasticity defines collective movements like epithelial sheet migration, branching morphogenesis, and streaming.

Conclusions:

  • Cell-cell adhesion systems are critical regulators of collective cell migration.
  • The plasticity of cell-cell junction composition and turnover determines migration coordination, anchorage, and dissociation.
  • Understanding these adhesion dynamics is key to deciphering collective cell plasticity.