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Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
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B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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Transcytosis of IgG01:15

Transcytosis of IgG

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Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
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Birth Control Methods01:22

Birth Control Methods

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Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Related Experiment Video

Updated: Mar 8, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
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Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

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B cells prevent preterm labor.

Leslie K Ferrarelli1

  • 1Science Signaling, AAAS, Washington, DC 20005, USA.

Science Signaling
|January 19, 2017
PubMed
Summary

Stimulating progesterone-induced blocking factor 1 (PIBF1) in uterine B cells may prevent premature labor. This approach could reduce neonatal mortality rates by enhancing uterine immune cell function.

Area of Science:

  • Immunology
  • Reproductive Biology
  • Perinatology

Background:

  • Premature labor is a leading cause of neonatal mortality.
  • The role of uterine immune cells, specifically B cells, in maintaining pregnancy is not fully understood.
  • Progesterone-induced blocking factor 1 (PIBF1) is a key cytokine involved in immune regulation during pregnancy.

Purpose of the Study:

  • To investigate the role of PIBF1 expression in uterine B cells during pregnancy.
  • To determine if stimulating PIBF1 expression can prevent premature labor.
  • To explore PIBF1 as a potential therapeutic target for reducing neonatal mortality.

Main Methods:

  • Analysis of PIBF1 expression levels in uterine B cells from pregnant and non-pregnant individuals.
  • In vitro studies using human uterine B cell cultures to assess the effects of PIBF1 stimulation.

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Related Experiment Videos

Last Updated: Mar 8, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
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Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

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Isolation of Leukocytes from the Human Maternal-fetal Interface
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  • Animal models of premature labor to evaluate the efficacy of PIBF1-enhancing interventions.

    • Main Results:

    • PIBF1 expression is significantly altered in uterine B cells during pregnancy.
    • Stimulation of PIBF1 in uterine B cells demonstrates immunomodulatory effects relevant to pregnancy maintenance.
    • Interventions aimed at increasing PIBF1 levels showed a reduction in premature labor incidence in preclinical models.

    Conclusions:

    • Uterine B cell PIBF1 expression is critical for successful pregnancy.
    • Targeting PIBF1 in uterine B cells represents a promising strategy for preventing premature labor.
    • This research opens new avenues for therapeutic interventions to decrease neonatal mortality.