Simamycin (5'-O-geranyluridine): a new prenylated nucleoside from Streptomyces sp
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From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
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Yasuhiro Igarashi1, Takayuki Kyoso1, Youngju Kim1
1Department of Biotechnology, Biotechnology Research Center, Toyama Prefectural University, Toyama, Japan.
The Journal of Antibiotics
|January 19, 2017
Abstract:
A new nucleoside modified by prenylation, simamycin (1), was isolated from the culture broth of a soil-derived Streptomyces sp. Its structure was determined by spectroscopic analysis and chemical synthesis as 5'-O-geranyluridine. Compound 1 induced differentiation of preadipocytes into matured adipocytes.
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