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Low dose intermittent 5-fluorouracil, epirubicin and cyclophosphamide (FEC) in poor risk patients with advanced
G Lelli1, A Tononi, P Bacchetti
1Oncology Department, S. Orsola-Malpighi Hospital, Bologna, Italy.
Journal of Chemotherapy (Florence, Italy)
|August 1, 1989
Abstract:
Fifteen patients with locally advanced or metastatic bladder carcinoma and with cardiac and/or renal impairment were treated with a combination of 5-fluorouracil, 400 mg/m2, epirubicin, 40 mg/m2, and cyclophosphamide, 400 mg/m2. No complete or partial remissions were observed among the 14 evaluable patients. The toxicity level was very low. We are now trying to "tailor" platinum-based combinations to renal function.