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Updated: Mar 8, 2026
Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
Published on: September 20, 2017
Hydrophobicity determines the fate of self-assembled fluorescent nanoparticles in cells
Arthur H A M van Onzen1, Lorenzo Albertazzi2, Albertus P H J Schenning3
1Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute of Complex Molecular Systems (ICMS), Eindhoven University of Technology, P.O. Box 513, 5600MB, Eindhoven, The Netherlands. l.brunsveld@tue.nl.
Abstract:
The fate of small molecule nanoparticles (SMNPs) composed of self-assembling intrinsically fluorescent π-conjugated oligomers was studied in cells as a function of side-chain hydrophobicity. While the hydrophobic SMNPs remained intact upon cellular uptake, the more hydrophilic SMNPs disassembled and dispersed throughout the cytosol.
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