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Update on Aspirin-Exacerbated Respiratory Disease
1Allergy, Asthma, and Immunology Division, Scripps Clinic Medical Group, 3811 Valley Centre Drive, San Diego, CA, 92130, USA. Woessner.katharine@scrippshealth.org.
Current Allergy and Asthma Reports
|January 19, 2017
Summary
Aspirin-exacerbated respiratory disease (AERD) involves airway inflammation and altered metabolism. This review covers recent findings on its pathophysiology and current management strategies, including aspirin desensitization.
Area of Science:
- Immunology
- Pulmonology
- Biochemistry
Background:
- Aspirin-exacerbated respiratory disease (AERD) is an acquired condition.
- It features chronic eosinophilic airway inflammation.
- Underlying dysregulation of arachidonic acid metabolism is observed.
Purpose of the Study:
- To review recent advancements in AERD pathophysiology.
- To highlight the roles of eosinophils, mast cells, innate lymphoid cells (ILC2), and platelets.
- To discuss clinical recognition and current management.
Main Methods:
- Literature review of recent developments in AERD.
- Focus on cellular and metabolic pathways.
- Analysis of clinical presentation and treatment efficacy.
Main Results:
- Eosinophils, mast cells, ILC2s, and platelets are key players in AERD pathophysiology.
- Specific clinical features like alcohol sensitivity, nasal polyposis, and anosmia aid in early diagnosis.
- Aspirin desensitization and high-dose aspirin remain central to AERD management.
Conclusions:
- Understanding AERD pathophysiology is advancing with insights into cellular roles.
- Early recognition through clinical signs is crucial.
- Current management emphasizes aspirin-based therapies.
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