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Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury

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Thromboelastography in Dogs with Chronic Hepatopathies.

W Fry¹, C Lester², N M Etedali³

¹Massachusetts Veterinary Referral Hospital, Woburn, MA.

Journal of Veterinary Internal Medicine

|January 19, 2017

Summary

This summary is machine-generated.

Thromboelastography (TEG) reveals variable coagulation in dogs with chronic hepatopathies (CH). Hypocoagulable TEG parameters indicate a negative prognosis, while hyperfibrinolysis suggests high disease activity.

Keywords:

Coagulation Fibrinolysis Hemostasis Liver

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Area of Science:

Veterinary Medicine
Hematology
Internal Medicine

Background:

Coagulation status in dogs with liver disease is challenging to predict using traditional tests.
Chronic hepatopathies (CH) significantly impact canine health and hemostasis.

Purpose of the Study:

To assess thromboelastography (TEG) findings in dogs with CH.
To correlate TEG results with conventional coagulation tests and disease severity indicators.

Main Methods:

Prospective and retrospective enrollment of 21 dogs with CH.
Kaolin-activated TEG analysis and comparison with reference intervals.
Correlation analysis of TEG parameters with coagulation assays and clinicopathologic data.

Main Results:

Dogs with CH exhibited altered TEG parameters, including prolonged R and K times, increased LY30, and decreased angles.
TEG results varied, categorizing dogs as normocoagulable, hypercoagulable, or hypocoagulable.
Specific TEG parameters correlated significantly with fibrinogen, PT, aPTT, protein C activity, and clinical scores.
Hyperfibrinolysis (elevated LY30) was linked to higher serum transaminase activities.
Portal hypertension correlated with hypocoagulable TEG patterns and prolonged PT.

Conclusions:

Thromboelastography demonstrates diverse coagulation profiles in dogs with chronic hepatopathies.
Hypocoagulable TEG parameters serve as negative prognostic indicators in canine CH.
Hyperfibrinolysis identified by TEG is associated with heightened disease activity in dogs with CH.