Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Perturb-seq screen guided by species divergence uncovers pathways for collateral artery formation.

bioRxiv : the preprint server for biology·2026
Same author

Engulfment by brain macrophages in a short-lived vertebrate.

bioRxiv : the preprint server for biology·2026
Same author

3D imaging of the pregnant uterus reveals an extensively invasive mouse placenta and early CXCL12-CXCR4 requirement.

bioRxiv : the preprint server for biology·2026
Same author

Discovery of a pre-vein progenitor that requires VEGF/ERK inhibition to complete vein differentiation.

bioRxiv : the preprint server for biology·2025
Same author

Vascularization of neonatal liver lobules presages adult liver size.

Nature communications·2025
Same author

Vascular organoids get a speed boost for regenerative repair.

Cell stem cell·2025

Related Experiment Video

Updated: Mar 8, 2026

Assessing Cardiomyocyte Subtypes Following Transcription Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts
09:29

Assessing Cardiomyocyte Subtypes Following Transcription Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts

Published on: March 22, 2017

7.9K

Cellular plasticity in cardiovascular development and disease.

Soumyashree Das1, Kristy Red-Horse1

  • 1Department of Biology, Stanford University, Stanford, California.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|January 19, 2017
PubMed
Summary
This summary is machine-generated.

Lineage tracing reveals diverse cell origins and surprising plasticity in cardiovascular development and disease. These findings challenge traditional views and suggest similar phenomena occur across multiple organ systems.

Keywords:
cardiovascular systemclonal analysisgenetic lineage tracingprogenitor cells

More Related Videos

Micropatterned Magneto-Rheological Elastomers to Drive Changes in Cardiomyocyte Alignment
08:10

Micropatterned Magneto-Rheological Elastomers to Drive Changes in Cardiomyocyte Alignment

Published on: June 10, 2025

679
Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform
10:42

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Published on: June 15, 2021

5.7K

Related Experiment Videos

Last Updated: Mar 8, 2026

Assessing Cardiomyocyte Subtypes Following Transcription Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts
09:29

Assessing Cardiomyocyte Subtypes Following Transcription Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts

Published on: March 22, 2017

7.9K
Micropatterned Magneto-Rheological Elastomers to Drive Changes in Cardiomyocyte Alignment
08:10

Micropatterned Magneto-Rheological Elastomers to Drive Changes in Cardiomyocyte Alignment

Published on: June 10, 2025

679
Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform
10:42

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Published on: June 15, 2021

5.7K

Area of Science:

  • Developmental Biology
  • Cellular Biology
  • Cardiovascular Science

Background:

  • Understanding cellular differentiation is crucial for organ development, homeostasis, and disease.
  • Lineage tracing experiments, involving permanent cell labeling, are key to studying cell fate.
  • Recent cardiovascular research has yielded unexpected insights into cellular origins and plasticity.

Purpose of the Study:

  • To summarize recent lineage tracing findings in the cardiovascular system.
  • To highlight the widespread applicability of these concepts in other organ systems.
  • To discuss the implications of multiple progenitor sources and cell plasticity.

Main Methods:

  • Review of recent lineage tracing experiments in the cardiovascular system.
  • Analysis of evidence for multiple progenitor sources for single cell types.
  • Examination of cell plasticity under disease conditions.

Main Results:

  • Cardiovascular organogenesis involves unexpected cellular origins.
  • Cells exhibit remarkable expansive capacities in disease settings.
  • Evidence suggests these concepts are prevalent across various organ systems.

Conclusions:

  • Cellular differentiation and plasticity are fundamental to organ development and disease.
  • Lineage tracing is a powerful tool for uncovering complex biological processes.
  • The findings underscore the dynamic nature of cell populations in health and disease.