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High serum YKL-40 level positively correlates with coronary artery disease
Yan Jin1, Jia-Ning Cao1, Chun-Xia Wang1
1Department of Cardiology, WuXi Second Hospital, Nanjing Medical University, 68 Zhongshan Road, Wuxi 214002, China.
Insights
Elevated levels of chitinase-like protein YKL-40 are positively correlated with coronary artery disease (CAD). YKL-40 may serve as a valuable diagnostic marker for CAD.
Area of Science:
- Biochemistry
- Cardiology
- Biomarkers
Background:
- Chitinase-like protein YKL-40 is implicated in inflammatory processes.
- The role of YKL-40 in coronary artery disease (CAD) requires further elucidation.
Purpose of the Study:
- To investigate the predictive value of serum YKL-40 levels in patients with coronary artery disease (CAD).
- To assess the correlation between YKL-40 levels and CAD severity.
Main Methods:
- Serum YKL-40 levels were measured in 116 CAD patients and 82 healthy controls.
- Coronary artery disease severity was quantified using Gensini scores.
- Spearman's correlation and receiver operating characteristic (ROC) curve analysis were employed.
Main Results:
- Serum YKL-40 levels were significantly higher in the CAD group compared to controls.
- A positive correlation was observed between serum YKL-40 levels and Gensini scores.
- An optimal YKL-40 cutoff of 127.7 ng/ml demonstrated 75.9% sensitivity and 57.3% specificity for CAD detection.
Conclusions:
- A positive association exists between YKL-40 levels and coronary artery disease.
- YKL-40 shows potential as an adjunctive biomarker for CAD diagnosis.
Aim:
We investigated the predictive value of chitinase-like protein YKL-40 in coronary artery disease (CAD).
Patients:
Serum YKL-40 levels in 116 CAD patients and 82 healthy controls were analyzed. Severity of CAD was evaluated using Gensini scores. Spearman's correlation was used to evaluate the correlation between Gensini scores and YKL-40 levels. The predictive value of YKL-40 was determined by receivers operating characteristic curve analysis.
Results:
Serum YKL-40 levels were significantly elevated in CAD group as compared with control group. A positive correlation was found between the serum YKL-40 level and Gensini score. The optimum cut-off value of YKL-40 concentration was 127.7 ng/ml for distinguishing CAD patients from healthy controls with a 75.9% sensitivity and 57.3% specificity.
Conclusion:
A positive correlation exists between YKL-40 levels and CAD, and YKL-40 might be a useful adjunct in the diagnosis of CAD.
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