Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs01:15

Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs

342
Bioequivalence experimental study designs play a pivotal role in testing the effectiveness of various treatments. Key among these are the repeated measures, cross-over, carry-over, and Latin square designs. In the repeated measures design, each subject receives all treatments, allowing for temporal comparisons. This type of design is useful in reducing variability but requires careful planning to avoid bias.The cross-over design, an economical method, involves sequential administration of...
342
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs01:20

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

347
Bioequivalence experimental study designs are crucial methodologies used in evaluating and comparing the bioavailability of different drug products. These designs are categorized into various types: completely randomized, randomized block, repeated measures, cross and carry-over, and Latin square designs.Completely randomized designs involve randomly allocating treatments to all subjects participating in the experiment. This allocation is achieved by assigning unique random numbers to subjects...
347
Experimental Designs01:16

Experimental Designs

18.4K
An experimental design is a systematic process that allows researchers to evaluate the relationship between dependent and independent variables. There are three widely used types of experimental design - pre-experimental design, true experimental design, and quasi-experimental design. In pre-experimental design, the researcher compares the data before and after some interventions or treatments. The true-experimental design has more than one purposefully created group, a commonly measured...
18.4K
Crossover Experiments01:16

Crossover Experiments

4.7K
Crossover experiments, also called the repeated-measurements design, is a study design in which all experimental units are exposed to all treatments in different periods. Crossover experiments are generally used in psychology, the pharmaceutical industry, agriculture, and medicine.
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.
4.7K
Factorial Design02:01

Factorial Design

14.9K
Factorial Analysis is an experimental design that applies Analysis of Variance (ANOVA) statistical procedures to examine a change in a dependent variable due to more than one independent variable, also known as factors. Changes in worker productivity can be reasoned, for example, to be influenced by salary and other conditions, such as skill level. One way to test this hypothesis is by categorizing salary into three levels (low, moderate, and high) and skills sets into two levels (entry level...
14.9K
Study Design in Statistics01:15

Study Design in Statistics

10.2K
A study design is a set of techniques that allow a researcher to collect and analyze data from different variables defined for a specific research problem. Statistics is commonly for effective study design and more robust experiments,
Does aspirin reduce the risk of heart attacks? Is one brand of fertilizer more effective at growing roses than another? Is fatigue as dangerous to a driver as the influence of alcohol? Questions like these are answered using randomized experiments with proper...
10.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Very low-carbohydrate ketogenic diet in treatment-naïve women with endometrial cancer and overweight: a randomized feasibility study.

Nature communications·2026
Same author

Prognostic comparison of the FIGO 2009 and 2023 endometrial cancer staging systems: a large, single-institution retrospective cohort study.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·2026
Same author

Preoperative hypoalbuminemia and survival among patients selected for primary cytoreduction in advanced ovarian cancer: A Memorial Sloan Kettering Cancer Center Team Ovary study.

Gynecologic oncology·2026
Same author

A Phase II Trial of Olaparib plus Pembrolizumab in Patients with Recurrent Copy Number-High/p53-Abnormal Endometrial Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Mastectomy for Breast Cancer in Nigeria: A Mixed-Methods Study of Barriers, Facilitators, and Patient Attitudes.

Psycho-oncology·2026
Same author

Age-Related Germline Landscape of Endometrial Cancer: Focus on Early-Onset Cases.

JCO precision oncology·2026
Same journal

Checking Genetic Homogeneity Between Two Samples Using Summary Statistics With Application to Mendelian Randomization.

Statistics in medicine·2026
Same journal

A Bayesian Learning Model for Joint Risk Prediction of Alcohol and Cannabis Use Disorders.

Statistics in medicine·2026
Same journal

Reluctant Transfer Learning in Penalized Regressions for Individualized Treatment Rules Under Effect Heterogeneity.

Statistics in medicine·2026
Same journal

Predictor-Assisted Nonparametric Graphical Models With Multivariate Error-Prone Data.

Statistics in medicine·2026
Same journal

Optimizing Treatment Decision Estimation for Right-Censored Survival Data Through Parameter Transfer Learning.

Statistics in medicine·2026
Same journal

Latent Class Log-Linear Models for Estimating Diagnostic Test Accuracy Without a Gold Standard: A Simulation Study.

Statistics in medicine·2026
See all related articles

Related Experiment Video

Updated: Mar 8, 2026

Methods for Presenting Real-world Objects Under Controlled Laboratory Conditions
06:54

Methods for Presenting Real-world Objects Under Controlled Laboratory Conditions

Published on: June 21, 2019

6.4K

An efficient basket trial design.

Kristen M Cunanan1, Alexia Iasonos1, Ronglai Shen1

  • 1Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 485 Lexington Ave. 2nd Floor, New York City, 10017, NY, U.S.A.

Statistics in Medicine
|January 19, 2017
PubMed
Summary
This summary is machine-generated.

This study introduces an improved basket trial design for targeted cancer therapies. By assessing response homogeneity early, it can increase efficiency when drugs are effective across multiple tumor types.

Keywords:
basket trialsmultiple comparisonsphase II clinical trialspower

More Related Videos

Barnes Maze Testing Strategies with Small and Large Rodent Models
12:59

Barnes Maze Testing Strategies with Small and Large Rodent Models

Published on: February 26, 2014

44.0K
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

11.4K

Related Experiment Videos

Last Updated: Mar 8, 2026

Methods for Presenting Real-world Objects Under Controlled Laboratory Conditions
06:54

Methods for Presenting Real-world Objects Under Controlled Laboratory Conditions

Published on: June 21, 2019

6.4K
Barnes Maze Testing Strategies with Small and Large Rodent Models
12:59

Barnes Maze Testing Strategies with Small and Large Rodent Models

Published on: February 26, 2014

44.0K
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

11.4K

Area of Science:

  • Oncology
  • Clinical Trials
  • Biostatistics

Background:

  • Targeted cancer therapies require new clinical trial designs due to specific mutation targets.
  • Basket trials test drugs across different cancer types harboring a common mutation.

Purpose of the Study:

  • To improve the efficiency of early-phase cancer clinical trials using a novel basket trial design.
  • To evaluate a strategy that assesses response homogeneity for potential basket aggregation in later stages.

Main Methods:

  • Simulations were used to compare the efficiency of a standard parallel basket trial design with a proposed adaptive design.
  • The adaptive design involves an interim analysis to assess response rate homogeneity across baskets.

Main Results:

  • The proposed adaptive basket trial design offers substantial efficiency gains when the targeted drug is effective in most or all tumor types.
  • Modest power losses may occur if the drug is effective in only a single basket, but overall efficiency can be improved.

Conclusions:

  • Adaptive basket trials can enhance the efficiency of targeted therapy development.
  • The optimal strategy depends on the drug's efficacy across different tumor types, necessitating careful consideration of trial design.