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Updated: Mar 8, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV

Published on: September 14, 2010

Angiosarcoma in HIV-negative patients is not associated with HHV-8.

João Avancini¹, José Antonio Sanches¹, Andre Pires Zanata Cherubim¹

¹Universidade de São Paulo (USP) - São Paulo (SP), Brazil.

Anais Brasileiros De Dermatologia

|January 19, 2017

Summary

Herpes virus 8 (HHV-8) was not detected in angiosarcoma samples. This study found no association between HHV-8 and angiosarcoma, supporting previous research on this aggressive vascular neoplasm.

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Area of Science:

Oncology
Virology
Pathogenesis

Background:

Angiosarcoma is an aggressive vascular or lymphatic neoplasm.
Herpes virus 8 (HHV-8) targets endothelial cells and can cause vascular neoplasms like Kaposi's sarcoma.
The specific role of HHV-8 in angiosarcoma development remains unclear.

Purpose of the Study:

To determine the presence of HHV-8 in angiosarcoma.
To investigate the potential link between HHV-8 and angiosarcoma pathogenesis.

Main Methods:

Polymerase chain reaction (PCR) was used to detect HHV-8 DNA.
Samples from angiosarcoma patients were analyzed.
Samples from patients with epidemic Kaposi's sarcoma served as controls.

Main Results:

HHV-8 was detected in all control cases of epidemic Kaposi's sarcoma.
HHV-8 was not detected in any of the angiosarcoma cases studied.

Conclusions:

The study found no association between HHV-8 and angiosarcoma.
These results align with prior research indicating HHV-8 is not implicated in angiosarcoma development.