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Related Concept Videos

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Related Experiment Video

Updated: Mar 8, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
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Subungual squamous cell carcinoma.

Carolina Barbosa de Sousa Padilha1, Laila Klotz de Almeida Balassiano1, Julyana Calegari Pinto1

  • 1Policlínica Geral do Rio de Janeiro (PGRJ) - Rio de Janeiro (RJ), Brazil.

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|January 19, 2017
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Summary

Subungual squamous cell carcinoma, a rare but common nail cancer, is often misdiagnosed as benign conditions. Early recognition and treatment are crucial for this underreported malignancy.

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Area of Science:

  • Dermatology
  • Oncology
  • Podiatry

Background:

  • Subungual squamous cell carcinoma (SCC) is the most common primary malignancy of the nail unit.
  • It frequently presents as benign lesions like fungal infections or warts, leading to diagnostic delays.
  • Physician awareness and diagnostic challenges contribute to its underreporting in medical literature.

Observation:

  • This report details a case of subungual SCC affecting the hallux (big toe).
  • The patient presented with symptoms mimicking common benign nail conditions.
  • Crucially, the diagnosis was made without evidence of bone involvement.

Findings:

  • The case highlights the diagnostic challenges posed by subungual SCC due to its varied presentation.
  • Despite its rarity, it represents the most frequent malignant neoplasm in the subungual location.
  • Prompt surgical intervention was performed for the diagnosed hallux subungual SCC.

Implications:

  • Increased physician awareness is necessary to improve early diagnosis of subungual SCC.
  • Distinguishing subungual SCC from benign conditions is critical for timely and appropriate patient management.
  • Further case reports are valuable for understanding the epidemiology and clinical behavior of this rare cancer.