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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Updated: Mar 8, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
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Transplantation tolerance: don't forget about the B cells.

A S Chong1, S H Khiew1

  • 1Section of Transplantation, Department of Surgery, The University of Chicago, Chicago, IL, USA.

Clinical and Experimental Immunology
|January 19, 2017
PubMed
Summary

Achieving transplantation tolerance is possible, with regulatory B cells (Bregs) and dysfunctional B cells playing key roles. These findings offer new diagnostic and therapeutic strategies for allograft tolerance.

Keywords:
BregsIL-10anergybiomarkerstransplantation tolerance

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Area of Science:

  • Immunology
  • Transplantation Science

Background:

  • Limited success in achieving indefinite graft survival without immunosuppression.
  • B cell signatures implicated in transplantation tolerance.
  • Emergence of regulatory B cells (Bregs) suggests a role in tolerance.

Purpose of the Study:

  • To review the roles of Bregs and dysfunctional B cells in transplantation tolerance.
  • To explore how these cells contribute to graft survival.
  • To identify new diagnostic and therapeutic approaches for allograft tolerance.

Main Methods:

  • Review of animal and human studies.
  • Analysis of B cell signatures and regulatory B cell functions.
  • Investigation of follicular regulatory T cells (Tfr) and their impact on B cells.

Main Results:

  • Bregs and dysfunctional B cells are implicated in promoting transplantation tolerance.
  • Regulatory B cells (Bregs) possess immune-modulatory functions.
  • Follicular regulatory T cells (Tfr) can suppress B cell function and induce epigenetic modifications.

Conclusions:

  • Bregs and dysfunctional B cells are critical for achieving and maintaining transplantation tolerance.
  • Understanding these cellular mechanisms provides a roadmap for new diagnostic biomarkers.
  • New therapeutic strategies targeting B cells can be developed to induce allograft tolerance.