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Urinary Incontinence in Alzheimer's Disease
Hsiang-Ying Lee1,2, Ching-Chia Li1,2,3,4, Yung-Shun Juan1,4,5
11 Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
American Journal of Alzheimer'S Disease and Other Dementias
|January 20, 2017
Summary
Patients with Alzheimer's disease (AD) have a significantly higher risk of urinary incontinence (UI). This study found a 1.54 hazard ratio for UI in AD patients, highlighting a critical health concern.
Area of Science:
- Gerontology
- Neurology
- Public Health
Background:
- Urinary incontinence (UI) is more common in elderly individuals with dementia, particularly Alzheimer's disease (AD).
- UI can exacerbate morbidity and mortality in AD patients.
Purpose of the Study:
- To evaluate the prevalence and annual incidence of UI in Taiwanese patients with AD.
- To determine the risk of UI in individuals with AD compared to those without.
Main Methods:
- A cohort of 933 AD patients was compared to a matched cohort of 2799 non-AD individuals from Taiwan's National Health Insurance Research Database.
- Cox proportional hazard regression and cumulative incidence ratio curves were used to assess UI risk and incidence.
- Prevalence and incidence rates were calculated, considering specific AD medications.
Main Results:
- The risk of UI was significantly higher in the AD cohort (Hazard Ratio: 1.54; 95% CI: 1.13-2.09).
- The cumulative incidence of UI events was statistically significant between the AD and non-AD cohorts (P < .001).
- Annual incidence and prevalence of UI in AD patients were 6.2% and 4.2%, respectively.
Conclusions:
- Patients with Alzheimer's disease face an elevated risk of urinary incontinence compared to the general population.
- These findings underscore the importance of managing UI in AD care to improve patient outcomes.
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