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[Association between risk factors during maternal pregnancy and the neonatal period and childhood bronchial asthma]

Hui-Qin Zhang1, Rui Fan, Jing-Jing Zhang

  • 1Department of Pediatrics, Xijing Hospital of Fourth Military Medical University, Xi'an 710032, China. sunxin6@ fmmu.edu.cn.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|January 20, 2017
PubMed

Insights

Maternal antibiotic use, preterm birth, and C-sections increase childhood asthma risk. Breastfeeding and probiotics offer protection, suggesting early prevention strategies for childhood asthma.

Area of Science:

  • Pediatrics
  • Allergy and Immunology
  • Public Health

Background:

  • Childhood bronchial asthma is a significant public health concern.
  • Identifying early-life risk factors is crucial for effective prevention strategies.

Purpose of the Study:

  • To investigate the association between maternal pregnancy and neonatal period risk factors and the development of childhood bronchial asthma.

Main Methods:

  • Retrospective study of 306 children with asthma and 250 healthy controls.
  • Analysis of maternal pregnancy and neonatal clinical data.

Main Results:

  • Antibiotic use during pregnancy and neonatal period, preterm birth, and cesarean section were identified as independent risk factors for childhood asthma.
  • Probiotic use and breastfeeding (>6 months) during the neonatal period demonstrated protective effects against childhood asthma.

Conclusions:

  • Reducing antibiotic exposure during pregnancy and the neonatal period is recommended.
  • Promoting breastfeeding and considering probiotic use in early life may help prevent childhood asthma.
Abstract

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