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[Study on the effect and predictive to bronchiectasis combined with rheumatoid arthritis]
1Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China.
Summary
Patients with rheumatoid arthritis and bronchiectasis (RA-BR) show higher disease severity and elevated anti-cyclic citrullinated peptide (anti-CCP) antibodies compared to bronchiectasis alone. Anti-CCP levels may predict bronchiectasis diagnosis and prognosis in RA patients.
Area of Science:
- Pulmonary Medicine
- Rheumatology
- Clinical Immunology
Background:
- Rheumatoid arthritis (RA) is a chronic autoimmune disease that can affect multiple organs, including the lungs.
- Bronchiectasis (BR) is a chronic respiratory condition characterized by irreversible dilatation of the bronchi.
- The coexistence of RA and BR presents unique clinical challenges and necessitates understanding their interrelationship.
Purpose of the Study:
- To investigate the clinical characteristics of patients with coexisting bronchiectasis and rheumatoid arthritis (RA-BR).
- To compare the clinical features, serological markers, and disease severity between RA-BR patients and patients with bronchiectasis alone (BR alone).
- To explore the potential role of anti-cyclic citrullinated peptide (anti-CCP) antibodies in predicting bronchiectasis severity in RA patients.
Main Methods:
- Retrospective analysis of 148 bronchiectasis patients diagnosed between January 2012 and December 2015.
- Comparison of general clinical features, serum anti-CCP, rheumatoid factor (RF), chest HRCT findings, and lung function between RA-BR and BR alone groups.
- Assessment of bronchiectasis severity using FACED scores and analysis of the correlation between anti-CCP levels and FACED scores.
Main Results:
- RA-BR patients exhibited significantly higher serum anti-CCP levels (196±68 vs. 64±26, P<0.05) compared to BR alone patients.
- FACED scores, indicating bronchiectasis severity, were significantly higher in the RA-BR group (5.2±1.8 vs. 3.1±1.4, P<0.05).
- Positive correlations were observed between serum anti-CCP levels and FACED scores in both RA-BR (r=0.678) and BR alone (r=0.461) groups (P<0.05).
Conclusions:
- Patients with coexisting rheumatoid arthritis and bronchiectasis demonstrate greater disease severity than those with bronchiectasis alone.
- Elevated serum anti-CCP levels may serve as a valuable biomarker for predicting the diagnosis and prognosis of bronchiectasis in patients with rheumatoid arthritis.
- Further research is warranted to elucidate the pathogenic mechanisms linking RA and BR and to optimize management strategies.
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