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Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization
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Paternal epigenetic programming: evolving metabolic disease risk.

Suzy S J Hur1,2, Jennifer E Cropley1,2, Catherine M Suter1,2

  • 1Victor Chang Cardiac Research InstituteDarlinghurst, New South Wales, Australia.

Journal of Molecular Endocrinology
|January 20, 2017
PubMed
Summary
This summary is machine-generated.

Paternal metabolic health, influenced by diet, can epigenetically impact offspring

Keywords:
RNAepigenetic inheritanceobesitypaternal effectssperm

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Area of Science:

  • Epigenetics
  • Metabolic Health
  • Developmental Biology

Background:

  • Parental health and environmental exposures influence offspring's lifetime health, independent of genetics.
  • While maternal metabolic effects are known, paternal contributions to offspring metabolic health are a recent discovery.
  • Paternal metabolic programming can span generations, suggesting acquired trait inheritance via sperm.

Purpose of the Study:

  • To review evidence for paternal programming of metabolism in humans and animal models.
  • To explore potential underlying mechanisms of sperm-based metabolic transmission.
  • To discuss the evolutionary significance of paternal metabolic programming.

Main Methods:

  • Review of human and animal model studies on paternal metabolic programming.
  • Analysis of evidence for transgenerational inheritance of acquired metabolic phenotypes.
  • Examination of sperm as a vector for epigenetic factors.

Main Results:

  • Paternal undernutrition and overnutrition induce metabolic phenotypes in offspring.
  • Evidence supports paternal metabolic programming across diverse animal species.
  • Sperm-based transmission is implicated in male lineage metabolic disease risk.

Conclusions:

  • Paternal metabolic programming is a significant factor in offspring metabolic health.
  • Epigenetic modifications in sperm mediate transgenerational metabolic effects.
  • This phenomenon likely holds evolutionary importance across species.