Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

872
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
872
Cancer Vaccines01:30

Cancer Vaccines

1.2K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.2K
Tumor Immunotherapy01:27

Tumor Immunotherapy

2.1K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.1K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.0K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.9K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.9K
Cancer Therapies02:49

Cancer Therapies

10.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunometabolic activation of neutrophils is associated with tissue factor-positive microparticles in gestational diabetes mellitus.

Polish archives of internal medicine·2026
Same author

National implementation of LOINC: translation methodology and experience from the Polish laboratory terminology standardization project.

Clinical chemistry and laboratory medicine·2026
Same author

Integrated analysis of IGHV rearrangements and cytogenetic abnormalities in a large chronic lymphocytic leukemia cohort (CLL-POL1).

BMC cancer·2026
Same author

Irisin may be involved in exendin-4 mitochondrial action in human adipocytes.

Archives of medical science : AMS·2026
Same author

N-terminal pro-B-type natriuretic peptide reference and cut-off values should be adjusted to patient's age in clinical practice - results of the PolSenior 2 national representative survey.

Kardiologia polska·2026
Same author

The Antioxidant Quercetin Affects Mitochondrial Function and Inhibits the Differentiation of Human Preadipocytes.

Molecules (Basel, Switzerland)·2026

Related Experiment Video

Updated: Mar 8, 2026

Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies
05:25

Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies

Published on: December 29, 2021

3.0K

Cannabinoids - a new weapon against cancer?

Małgorzata Pokrywka1, Joanna Góralska1, Bogdan Solnica1

  • 1Katedra Biochemii Klinicznej, Uniwersytet Jagielloński Collegium Medicum.

Postepy Higieny I Medycyny Doswiadczalnej (Online)
|January 20, 2017
PubMed
Summary

Cannabis compounds, known as cannabinoids, show potential in cancer treatment by inducing cancer cell death (apoptosis). However, further research is needed to understand their complex effects and develop safe therapies.

More Related Videos

Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents
03:43

Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents

Published on: August 22, 2025

616
Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

1.2K

Related Experiment Videos

Last Updated: Mar 8, 2026

Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies
05:25

Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies

Published on: December 29, 2021

3.0K
Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents
03:43

Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents

Published on: August 22, 2025

616
Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

1.2K

Area of Science:

  • Pharmacology
  • Oncology
  • Molecular Biology

Background:

  • Cannabis has historical uses, including medicinal applications.
  • The discovery of Δ9-tetrahydrocannabinol and cannabinoid receptors (CB1, CB2) advanced the study of Cannabis sativa.
  • Scientific evidence suggests cannabinoids may have anti-cancer properties.

Purpose of the Study:

  • To review the potential of cannabinoids in cancer therapy.
  • To explore the molecular mechanisms underlying cannabinoid action on cancer cells.
  • To identify the need for further research into cannabinoid-based cancer treatments.

Main Methods:

  • In vitro studies on cancer cell lines.
  • In vivo experiments on animal models.
  • Analysis of scientific literature on cannabinoid effects.

Main Results:

  • Cannabinoids (phyto-, endo-, synthetic) can inhibit tumor growth, proliferation, neo-angiogenesis, and metastasis.
  • Apoptosis is a key mechanism for cannabinoid-induced cancer cell death, often linked to endoplasmic reticulum stress and autophagy.
  • Cannabinoids can also promote tumor cell proliferation in certain contexts by modulating immune responses and mitogenic factors.

Conclusions:

  • Cannabinoids demonstrate dual effects on cancer cells, with potential therapeutic benefits and risks.
  • Understanding the complex molecular pathways of cannabinoids is crucial for developing safe and effective cancer drugs.
  • Further research is essential to harness the full therapeutic potential of cannabinoids in oncology.