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Serum Monokine Induced by Gamma Interferon Is Associated With Severity of Coronary Artery Disease

Youfeng Liang1, Chun Yang, Qi Zhou

  • 1Department of Cardiology, Hefei Third Clinical College of Anhui Medical University.

International Heart Journal
|January 20, 2017
PubMed

Insights

Serum levels of monokine induced by gamma interferon (MIG) correlate with coronary artery disease severity. This finding suggests MIG may play a role in early atherosclerosis development.

Area of Science:

  • Immunology
  • Cardiology
  • Biochemistry

Background:

  • Immune system involvement in cardiovascular disease pathogenesis is increasingly recognized.
  • T-cell responses are implicated in atherosclerosis and hypertension, but specific chemokine roles in coronary artery disease remain unclear.

Purpose of the Study:

  • To investigate the association between serum monokine induced by gamma interferon (MIG/CXCL9) levels and the severity of coronary artery disease.
  • To determine if MIG levels are independently associated with coronary artery disease severity.

Main Methods:

  • Serum levels of MIG, CD40L, and IFN-γ were measured in 117 coronary heart disease patients and 80 controls.
  • Coronary artery disease severity was assessed using coronary artery angiography and the Gensini score.

Main Results:

  • A significant positive correlation was found between serum MIG levels and the Gensini score (r = 0.122, P = 0.009).
  • Multivariate regression analysis confirmed that serum MIG levels were independently associated with coronary artery disease severity (β = 0.100, P = 0.021).

Conclusions:

  • Serum MIG levels are significantly correlated with the severity of coronary artery disease.
  • MIG may serve as a potential biomarker for early coronary artery atherosclerosis in humans.

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