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Updated: Mar 8, 2026
FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
A complex translocation (3;17;15) in acute promyelocytic leukemia confirmed by fluorescence in situ hybridization
Yanming Wang1, Junjie Ma2, Xinguang Liu3
1Department of Hematology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China; Department of Hematology, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China.
Abstract:
Acute promyelocytic leukemia (APL) is typified by t(15;17)(q22;q21), generating the promyelocytic leukemia (PML) gene at 15q22 with the retinoic acid α-receptor (RARA) gene at 17q21. The PML-RARA fusion gene is believed to play a vital role in leukemogenesis. A sizeable minority of patients with complex variants of APL have been reported. The present study reports the case of a 33-year-old male with APL carrying a potential complex translocation. The initial symptom was bleeding gums. Chromosomal analysis of the bone marrow cells revealed an atypical 17q aberration. Fluorescence in situ hybridization further indicated that 92% of analyzed cells were positive for the PML-RARA fusion gene. The patient experienced complete remission following treatment with arsenic trioxide and chemotherapy. The atypical translocations in acute promyelocytic leukemia require further investigation.
