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Related Experiment Video

Updated: Mar 8, 2026

Author Spotlight: Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas

Author Spotlight: Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas

Published on: July 21, 2023

Asymmetric split H-shape nanoantennas for molecular sensing.

I G Mbomson¹, S Tabor¹, B Lahiri¹

¹School of Engineering, University of Glasgow, Glasgow, G12 8LT, UK.

Biomedical Optics Express

|January 20, 2017

Summary

This summary is machine-generated.

This study introduces a highly sensitive biosensor using gold asymmetric nanoantennas to detect C-H bonds. The novel biosensor achieves significant molecular resonance enhancement for detecting 17β-estradiol (E2).

Keywords:

(130.6010) Sensors (250.5403) Plasmonics

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DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

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Published on: September 27, 2019

Area of Science:

Plasmonics
Nanotechnology
Biosensing

Background:

C-H bond vibrational resonances are crucial for molecular detection.
Existing biosensing methods often lack sufficient sensitivity for certain analytes.
Plasmonic nanoantennas offer potential for enhancing molecular signals.

Purpose of the Study:

To develop a highly sensitive biosensor for detecting C-H bond vibrations.
To utilize gold asymmetric nanoantennas for signal enhancement.
To assay the detection of 17β-estradiol (E2) using the developed biosensor.

Main Methods:

Fabrication of gold asymmetric-split H-shape (ASH) nanoantenna arrays.
Tuning nanoantennas to achieve plasmonic resonances overlapping with C-H bond vibrational resonances.
Measurement and numerical simulation of reflectance spectra for deposited 17β-estradiol (E2) films.
Analysis of enhancement factors and sensitivity.

Main Results:

Demonstrated molecular resonance enhancement of C-H bonds by a factor of approximately 10⁵.
Achieved a high sensitivity of 2335 nm/RIU for 17β-estradiol (E2) detection.
Obtained a figure of merit of approximately 8 for the biosensor.
Experimental results were validated through numerical simulations.

Conclusions:

Gold asymmetric nanoantennas are effective for enhancing molecular resonances of C-H bonds.
The developed ASH nanoantenna array biosensor exhibits high sensitivity and a good figure of merit.
This technology shows promise for sensitive molecular detection and analysis.