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FGF23 and inflammation.

Usama A A Sharaf El Din1, Mona M Salem1, Dina O Abdulazim1

  • 1Usama A A Sharaf El Din, Department of Nephrology, School of Medicine, Cairo University, Nasr City, Cairo 11759, Egypt.

World Journal of Nephrology
|January 20, 2017
PubMed
Summary
This summary is machine-generated.

Systemic inflammation is common in chronic kidney disease (CKD). Fibroblast growth factor 23 (FGF23) directly stimulates this inflammation, explaining its link to vascular calcification and mortality in CKD patients.

Keywords:
Chronic kidney diseaseFGF23InflammationPhosphate bindersVascular calcification

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Area of Science:

  • Nephrology
  • Cardiovascular Science
  • Inflammation Research

Background:

  • Systemic inflammation is a hallmark of chronic kidney disease (CKD).
  • The contribution of inflammation to vascular calcification in CKD is established.
  • Fibroblast growth factor 23 (FGF23) is implicated in CKD complications.

Purpose of the Study:

  • To investigate the role of FGF23 in driving systemic inflammation in CKD.
  • To elucidate the mechanism linking FGF23 to vascular calcification.
  • To understand the association between FGF23, inflammation, and mortality in CKD.

Main Methods:

  • Review of existing literature on CKD, inflammation, and FGF23.
  • Analysis of studies investigating FGF23's direct effects on inflammatory pathways.
  • Correlation analysis of FGF23 levels with markers of inflammation and vascular calcification.

Main Results:

  • FGF23 is identified as a direct stimulus of systemic inflammation.
  • This inflammatory action of FGF23 provides a mechanistic link to vascular calcification.
  • Elevated FGF23 levels are strongly associated with increased vascular calcification and mortality in CKD.

Conclusions:

  • FGF23 plays a direct role in promoting systemic inflammation in CKD.
  • This mechanism explains the observed association between FGF23 and adverse cardiovascular outcomes.
  • Targeting FGF23-mediated inflammation may offer therapeutic strategies for CKD patients.