Signaling Pathways in Cardiac Myocyte Apoptosis

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Updated: Mar 8, 2026

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

9.2K

Peng Xia1, Yuening Liu1, Zhaokang Cheng1

  • 1Department of Pharmaceutical Sciences, Washington State University College of Pharmacy, PBS 323, 205 E. Spokane Falls Blvd., P.O. Box 1495, Spokane, WA 99210-1495, USA.

Biomed Research International
|January 20, 2017
PubMed

Insights

Cardiovascular diseases are linked to cardiac myocyte apoptosis. Targeting these cell death pathways offers potential therapeutic strategies for heart conditions, but clinical treatments are still needed.

Area of Science:

  • Cardiology and Molecular Biology
  • Cellular mechanisms of cardiovascular disease

Background:

  • Cardiovascular diseases are the leading global cause of death.
  • Apoptotic death of cardiac myocytes is a common feature of cardiovascular diseases.
  • Targeting cardiomyocyte apoptosis presents a potential therapeutic avenue for various heart disorders.

Purpose of the Study:

  • To summarize current knowledge on cardiomyocyte apoptosis pathways.
  • To highlight the role of these pathways in heart disease pathogenesis.
  • To review the translation of this knowledge from research to clinical practice.

Main Methods:

  • Review of recent scientific literature on cardiomyocyte apoptosis.
  • Focus on signaling molecules and pathways regulating apoptosis in cardiac myocytes.
  • Analysis of bench-to-bedside translation of findings.

Main Results:

  • Multiple signaling molecules and pathways regulate cardiomyocyte apoptosis.
  • These pathways are implicated in the pathogenesis of heart disease.
  • Current clinical treatments targeting apoptosis are limited.

Conclusions:

  • Understanding cardiomyocyte apoptosis is crucial for developing new therapies.
  • Further research is needed to translate basic science findings into clinical applications.
  • Identifying and targeting specific apoptosis pathways may offer novel treatments for cardiovascular diseases.

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