Discriminating Valid from Spurious Indices of Phase-Amplitude Coupling
Ole Jensen1, Eelke Spaak2, Hyojin Park3
1Centre for Human Brain Health, School of Psychology, University of Birmingham , Birmingham B15 2TT, United Kingdom.
Eneuro
|January 20, 2017
Summary
Cross-frequency coupling, the interaction between brain oscillations, is crucial. This study provides guidance on trusting phase-amplitude coupling measures, offering control analyses and empirical examples for reliable identification.
Area of Science:
- Neuroscience
- Computational Neuroscience
- Signal Processing
Background:
- Cross-frequency coupling (CFC) is a key area of interest in neuroscience, examining interactions between neuronal oscillations in different frequency bands.
- Phase-amplitude coupling (PAC), a specific type of CFC, measures the relationship between the phase of slow oscillations and the amplitude of fast oscillations.
- Existing PAC measures have faced criticism for potential spurious detection due to nonsinusoidal oscillation properties.
Purpose of the Study:
- To address concerns regarding the reliability of phase-amplitude coupling measures.
- To provide concrete examples and criteria for trusting identified cross-frequency coupling.
- To offer practical advice for researchers on validating PAC findings.
Main Methods:
- The study relies on control analyses and empirical observations, rather than solely signal-processing tools.
- Illustrative examples are presented to demonstrate trustworthy PAC identification.
- Methodological critiques of existing PAC measures are discussed.
Main Results:
- Spurious detection of PAC can occur due to nonsinusoidal signal properties.
- Trustworthy PAC identification is demonstrated through specific control analyses and empirical data.
- The commentary differentiates between genuine and artifactual PAC.
Conclusions:
- Researchers can confidently identify cross-frequency coupling when employing rigorous control analyses and empirical validation.
- The study offers practical guidelines to ensure the trustworthiness of phase-amplitude coupling findings.
- This work aims to enhance the reliability of PAC as a neuroscientific tool.
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