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Role of Skin in Vitamin D Synthesis01:23

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
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Vitamins

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Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
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[All-rounder vitamin D?]

S Unholzer1,2,3, A Rothmund4, E Haen5,4,6

  • 1AG Klinische Pharmakologie, Poliklinik für Psychiatrie und Psychotherapie, Bezirksklinikum Regensburg, Universitätsstr. 84, 93053, Regensburg, Deutschland. sandra.unholzer@klinik.uni-regensburg.de.

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Summary
This summary is machine-generated.

Vitamin D supplementation shows inconsistent results for various diseases, with established benefits for rickets and osteoporosis. Standardization of vitamin D testing methods is needed due to varying results.

Keywords:
CholecalciferolHypertensionPreventionPsychiatric diseasesVitamin D deficiency

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Area of Science:

  • Endocrinology
  • Nutritional Science
  • Public Health

Background:

  • Vitamin D deficiency is prevalent in Germany, with proposed roles in osteoporosis, autoimmune, cancer, and psychiatric diseases.
  • Numerous indications for vitamin D supplementation are under investigation.

Purpose of the Study:

  • To review evidence for vitamin D in various diseases.
  • Critically analyze the established therapeutic reference range for vitamin D deficiency.

Main Methods:

  • Literature search of German Society for Nutrition statements.
  • Review of scientific publications and journals.

Main Results:

  • Inconsistent study results regarding vitamin D's efficacy in disease prevention and therapy.
  • Established indications include rickets prevention and osteoporosis support.
  • Current vitamin D deficiency ranges are based on parathyroid hormone levels.
  • Variability exists in laboratory vitamin D measurement methods.

Conclusions:

  • Further research is required to elucidate vitamin D's role in diverse diseases.
  • Lack of standardized measurement methods leads to incomparable results.
  • Standardization of vitamin D assays is highly desirable.