Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anatomy of the Intestines01:23

Anatomy of the Intestines

89.0K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
89.0K
Physiology of Enteric Nervous System and Gut Health01:05

Physiology of Enteric Nervous System and Gut Health

1.1K
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
1.1K
Defense Mechanism Against Infection01:26

Defense Mechanism Against Infection

10.2K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
10.2K
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors01:24

Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors

1.4K
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI)  tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
1.4K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

991
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
991
Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

1.8K
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of pasteurized <i>Akkermansia muciniphila</i> MucT on insulin sensitivity, body composition, and GLP-1 production in subjects with metabolic syndrome: impact of low baseline gut <i>Akkermansia</i> levels.

Gut microbes·2026
Same author

Dietary chicory rhamnogalacturonan-I modulates gut microbiota and immune responses in healthy adults.

Microbiome research reports·2026
Same author

Microbiome signatures correlate with diet-mediated ADHD symptom reduction.

Gut microbes·2026
Same author

The lipid transfer protein STARD7 controls intestinal tumor development in a context-dependent manner.

EMBO molecular medicine·2026
Same author

Association of nasopharyngeal <i>Dolosigranulum pigrum</i> and <i>Corynebacterium</i> species with post-acute sequelae of SARS-CoV-2 in a longitudinal cohort.

Microbiology spectrum·2026
Same author

The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of gut health.

Nature reviews. Gastroenterology & hepatology·2026

Related Experiment Video

Updated: Mar 8, 2026

Investigating Intestinal Barrier Breakdown in Living Organoids
07:18

Investigating Intestinal Barrier Breakdown in Living Organoids

Published on: March 26, 2020

14.4K

Can probiotics modulate human disease by impacting intestinal barrier function?

Peter A Bron1, Michiel Kleerebezem2, Robert-Jan Brummer3

  • 11NIZO Food Research and BE-Basic Foundation,Kernhemseweg 2,6718ZB Ede,The Netherlands.

The British Journal of Nutrition
|January 20, 2017
PubMed
Summary
This summary is machine-generated.

Disrupted intestinal barrier integrity contributes to gastrointestinal diseases. This review explores how probiotics may restore barrier function and alleviate symptoms, promoting gut health.

Keywords:
CD Crohn’s diseaseNEC necrotising enterocolitisTJ tight junctionTLR Toll-like receptorUC ulcerative colitisGastrointestinal disordersGut barrierGut microbiotaImmunityProbiotics

More Related Videos

Assessment of Gut Barrier Integrity in Mice Using Fluorescein-Isothiocyanate-Labeled Dextran
05:14

Assessment of Gut Barrier Integrity in Mice Using Fluorescein-Isothiocyanate-Labeled Dextran

Published on: November 18, 2022

12.8K
An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

10.6K

Related Experiment Videos

Last Updated: Mar 8, 2026

Investigating Intestinal Barrier Breakdown in Living Organoids
07:18

Investigating Intestinal Barrier Breakdown in Living Organoids

Published on: March 26, 2020

14.4K
Assessment of Gut Barrier Integrity in Mice Using Fluorescein-Isothiocyanate-Labeled Dextran
05:14

Assessment of Gut Barrier Integrity in Mice Using Fluorescein-Isothiocyanate-Labeled Dextran

Published on: November 18, 2022

12.8K
An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

10.6K

Area of Science:

  • Gastroenterology and Microbiology
  • Gut Microbiome Research
  • Epithelial Biology

Background:

  • Intestinal barrier integrity is crucial for maintaining gut homeostasis and defense against pathogens.
  • Disruption of this barrier is linked to various gastrointestinal diseases, including inflammatory bowel disease and obesity.
  • Probiotics are being investigated for their potential to modulate intestinal barrier function.

Purpose of the Study:

  • To review and categorize existing evidence on the role of probiotics in maintaining and restoring intestinal epithelial integrity.
  • To assess the potential of specific probiotic strains in improving gastrointestinal health.
  • To understand how probiotics contribute to the reduction of gastrointestinal disease symptoms.

Main Methods:

  • Literature review and categorization of evidence from in vitro cell line studies.
  • Analysis of data from animal models investigating probiotic effects on gut barrier function.
  • Evaluation of clinical trial outcomes assessing probiotic interventions for gastrointestinal disorders.

Main Results:

  • Evidence suggests certain probiotic strains can positively influence intestinal epithelial barrier function.
  • Probiotics demonstrate potential in mitigating disease states associated with barrier disruption.
  • The review categorizes diverse lines of evidence supporting probiotics' role in gut health.

Conclusions:

  • Probiotics show promise as a therapeutic strategy for improving intestinal barrier integrity.
  • Restoration of epithelial barrier function by probiotics may reduce symptoms of various gastrointestinal diseases.
  • Further research is warranted to elucidate specific mechanisms and optimize probiotic applications.