Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Morphogenesis02:19

Morphogenesis

30.6K
Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
30.6K
Forced Transdifferentiation01:28

Forced Transdifferentiation

2.4K
Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial...
2.4K
Gastrulation01:56

Gastrulation

68.3K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
68.3K
Cellular Differentiation00:57

Cellular Differentiation

6.0K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
6.0K
Cell Migration01:19

Cell Migration

7.1K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
7.1K
Cell Migration01:09

Cell Migration

19.0K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
19.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A scalable human-zebrafish xenotransplantation model reveals gastrosome-mediated processing of dying neurons by human microglia.

Communications biology·2026
Same author

Optogenetic mediated contractility enables reversible control of microglial morphology and migration in vivo.

Cell reports·2026
Same author

Developing evidence-based, cost-effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities.

Molecular oncology·2025
Same author

In toto analysis of embryonic organisation reduces tissue diversity to two archetypes requiring specific cadherins.

Nature communications·2025
Same author

Highly dynamic mechanical transitions in embryonic cell populations during Drosophila gastrulation.

Nature communications·2025
Same author

Differential regulation of the proteome and phosphoproteome along the dorso-ventral axis of the early <i>Drosophila</i> embryo.

eLife·2024
Same journal

Six ways to put the public at the heart of science and policy.

Nature·2026
Same journal

The complex truth about trust in science.

Nature·2026
Same journal

Have people stopped trusting science? The data tell a surprising story.

Nature·2026
Same journal

How FAIR data are helping to build trust in science.

Nature·2026
Same journal

Scientists should recognize their own political biases to build public trust.

Nature·2026
Same journal

Harmonizing standards and resources for the medical genome.

Nature·2026
See all related articles

Related Experiment Video

Updated: Mar 8, 2026

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
09:16

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Published on: January 30, 2014

11.7K

From morphogen to morphogenesis and back.

Darren Gilmour1, Martina Rembold2,3, Maria Leptin1,2

  • 1European Molecular Biology Laboratory, 69117 Heidelberg, Germany.

Nature
|January 20, 2017
PubMed
Summary
This summary is machine-generated.

Scientists are uncovering how genomes dictate organismal shape by linking gene control of cell fate to cellular machinery. This research bridges the genotype-phenotype gap, advancing understanding of robust organ assembly and tissue engineering.

More Related Videos

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients
08:10

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients

Published on: December 14, 2015

11.9K
Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions
07:18

Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions

Published on: October 27, 2023

3.4K

Related Experiment Videos

Last Updated: Mar 8, 2026

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
09:16

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Published on: January 30, 2014

11.7K
Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients
08:10

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients

Published on: December 14, 2015

11.9K
Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions
07:18

Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions

Published on: October 27, 2023

3.4K

Area of Science:

  • Developmental Biology
  • Genomics
  • Biophysics

Background:

  • Understanding the genome's role in organismal shape is a key goal in life sciences.
  • Bridging the gap between genotype and phenotype requires linking genetic control of cell fate to cellular shape-generating mechanisms.

Purpose of the Study:

  • To identify mechanistic links between genes controlling cell fate and cellular machinery generating shape.
  • To elucidate the logic and mechanisms integrating different levels of shape control.
  • To provide a framework for tissue engineering based on a comprehensive understanding of morphogenesis.

Main Methods:

  • Investigating genetic control of cell-fate decisions.
  • Analyzing cellular machines responsible for generating biological shape.
  • Studying mechanisms of cross-talk and feedback in organ assembly.

Main Results:

  • Mechanistic links between genes and cellular shape generation are being identified.
  • Integration logic and mechanisms for shape control are emerging.
  • Cross-talk and feedback mechanisms contribute to the robustness of organ assembly.

Conclusions:

  • A 'full-circle' understanding of morphogenesis is emerging.
  • This understanding solves a key puzzle in biology.
  • The findings provide a framework for future tissue engineering approaches.