Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Immunopotentiation and pregnancy loss.

V Toder¹, D Strassburger, H Carp

¹Department of Embryology & Teratology, Tel-Aviv University Medical School, Israel.

Journal of Reproduction and Fertility. Supplement

|January 1, 1989

Summary

Maternal immune system stimulation, particularly with complete Freund

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Enhanced immunogenicity of multivalent MUC1 glycopeptide antitumour vaccines based on hyperbranched polymers.

Organic & biomolecular chemistry·2015

Same author

Thymic hormones: inducers and.

Immunology today·2014

Same author

Effect of seminal plasma application to the vaginal vault in in vitro fertilization or intracytoplasmic sperm injection treatment cycles-a double-blind, placebo-controlled, randomized study.

Journal of assisted reproduction and genetics·2013

Same author

Surrogate in vitro fertilization outcome in typical and atypical forms of Mayer-Rokitansky-Kuster-Hauser syndrome.

Human reproduction (Oxford, England)·2011

Same author

Presence of IL-18 in testicular tissue of fertile and infertile men.

Andrologia·2011

Same author

EGF-like growth factors as LH mediators in the human corpus luteum.

Human reproduction (Oxford, England)·2008

Area of Science:

Immunology
Reproductive Biology
Developmental Biology

Background:

Recurrent pregnancy loss is a significant concern.
The maternal immune system's role in successful pregnancy is complex.
Immunopotentiation strategies are being explored to improve reproductive outcomes.

Purpose of the Study:

To investigate if enhancing the maternal immune system benefits embryo development.
To assess the effects of specific and non-specific immune stimulation on pregnancy success.
To determine the impact of immunopotentiation on fetal resorption rates.

Main Methods:

Examined specific pre-immunization with paternal leukocytes in women and splenocytes in mice.
Assessed the influence of non-specific immune potentiators (complete Freund's adjuvant, thymus humoral factor) on abortion rates.
Utilized flow cytometry to analyze lymphocyte subpopulations (L3H4, Lyt-2).

Main Results:

Specific immunization led to successful pregnancy in 76% of habitually aborting women.
Complete Freund's adjuvant significantly decreased fetal resorption rates in mice (11.3% vs 34.9%).
A slight decrease in splenic L3H4-positive lymphocytes was observed post-treatment, but Lyt-2 levels remained unchanged. Thymus humoral factor had no effect.

Conclusions:

Non-specific immune stimulation with complete Freund's adjuvant can enhance reproductive success in mice with pregnancy loss.
The precise mechanism underlying this improvement remains unclear and may not involve systemic cellular mechanisms.
Further research is needed to elucidate the pathways involved in immune-mediated reproductive success.

Related Experiment Videos