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Updated: Mar 8, 2026

Generation of Mice Derived from Induced Pluripotent Stem Cells

Generation of Mice Derived from Induced Pluripotent Stem Cells

Published on: November 29, 2012

Totipotency in the mouse.

Guangming Wu¹, Lei Lei^1,2, Hans R Schöler^3,4

¹Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149, Münster, Germany.

Journal of Molecular Medicine (Berlin, Germany)

|January 20, 2017

Summary

This summary is machine-generated.

Mammalian zygotes possess totipotency, the ability to form all cell types. This review explores the molecular mechanisms and transcriptional regulation underlying this crucial early developmental stage in mouse embryos.

Keywords:

Totipotency Transcription factors Zygote

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Area of Science:

Developmental Biology
Genetics
Epigenetics

Background:

Mammalian embryogenesis begins with a unicellular zygote.
The zygote differentiates into diverse somatic cells, forming fetal and extraembryonic lineages.
Totipotency enables the zygote to develop into a complete organism with over 200 tissue types.

Purpose of the Study:

To review recent findings on the molecular properties of totipotency.
To elucidate the molecular signature of totipotent cells.
To understand the transcriptional regulation networks governing totipotency in mouse embryos.

Main Methods:

Literature review of recent findings.
Analysis of molecular signatures.
Examination of transcriptional regulation mechanisms.

Main Results:

Oocyte maternal factors reprogram parental genomes upon fertilization.
The zygote is established as a totipotent cell.
Key molecular properties and regulatory networks of totipotency are being uncovered.

Conclusions:

Totipotency is a fundamental property of the early mammalian zygote.
Understanding totipotency requires investigating molecular signatures and transcriptional networks.
Further research is needed to fully comprehend the mechanisms of totipotency.