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Dynamic sentinel node biopsy for penile cancer: an initial experience in an Irish Hospital
P E Lonergan1, A Nic An Riogh2, F O'Kelly2
1Department of Urology, Mater Misericordiae University Hospital, Eccles Street, Dublin 7, Ireland. peterlonergan@rcsi.ie.
Irish Journal of Medical Science
|January 20, 2017
Summary
Dynamic sentinel node biopsy (DSNB) accurately assesses lymph node status in penile cancer patients. This minimally invasive technique helps identify occult metastases in clinically node-negative cases, improving prognosis.
Area of Science:
- Urology
- Surgical Oncology
- Oncology
Background:
- Nodal metastases are critical prognostic factors in penile cancer.
- Assessing nodal status in clinically node-negative (cN0) penile cancer patients is challenging.
- Current imaging methods are insufficient for detecting micrometastatic disease.
Purpose of the Study:
- To evaluate the initial experience with dynamic sentinel node biopsy (DSNB).
- To assess the status of regional lymph nodes in cN0 penile cancer patients using DSNB.
Main Methods:
- DSNB was performed on cN0 penile cancer patients with at least one cN0 groin.
- Lymphoscintigraphy was conducted after intradermal injection of Technetium-99m nanocolloid.
- Sentinel nodes were identified using lymphoscintigraphy and intraoperative gamma probe detection.
Main Results:
- 18 groins from 11 patients underwent DSNB (mean age 63 years).
- A mean of 1.2 sentinel nodes were retrieved per groin.
- One patient had a positive lymph node, subsequently treated with inguinal lymph node dissection; no recurrences were observed during a median follow-up of 12.8 months.
Conclusions:
- DSNB is a feasible technique for staging penile cancer in cN0 patients.
- Further studies with more cases and longer follow-up are needed to establish DSNB accuracy in the Irish population.
