Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An Overview of Oropouche Virus Disease.

The Neurohospitalist·2026
Same author

Chimeric Antigen Receptor T-Cell Therapy in Autoimmune Disorders: An Expert Panel Opinion From the American Society for Transplantation and Cellular Therapy.

Transplantation and cellular therapy·2026
Same author

Complement Inhibition for Acute Neuromyelitis Optica Spectrum Disorder Attacks: Insights From an International Case Series.

Neurology(R) neuroimmunology & neuroinflammation·2026
Same author

The history of paraneoplastic neurologic disorders of the CNS, PNS, and autonomic nervous systems: Perspective on the past toward a brighter future.

Handbook of clinical neurology·2026
Same author

Assessing Real-World Utilization/Performance of Salivary Gland Biopsy in Diagnosis of Sjögren Disease: Impact of Overweighting Without Objective Glandular Testing.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2025
Same author

Medicare Part D Use and Costs for Immune-Mediated Neurologic Therapies.

JAMA network open·2025

Related Experiment Video

Updated: Mar 8, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

7.2K

NMDAR Encephalitis Following Herpes Simplex Virus Encephalitis.

Jonathan Galli1, Stacey L Clardy1, Amanda L Piquet2

  • 1Department of Neurology, University of Utah, Salt Lake City, UT, USA.

Current Infectious Disease Reports
|January 20, 2017
PubMed
Summary

Herpes simplex virus encephalitis (HSVE) can trigger autoimmune N-methyl-D-aspartate receptor (NMDAR) encephalitis weeks after infection. Research explores this link and potential immunotherapy to prevent autoimmune responses.

Keywords:
AutoimmuneCell surface antibodyEncephalitisHerpes simplex virusN-methyl-D-aspartate receptor (NMDAR) antibody

More Related Videos

A Simple Cell-based Immunofluorescence Assay to Detect Autoantibody Against the N-Methyl-D-Aspartate NMDA Receptor in Blood
07:20

A Simple Cell-based Immunofluorescence Assay to Detect Autoantibody Against the N-Methyl-D-Aspartate NMDA Receptor in Blood

Published on: January 9, 2018

10.5K
High-throughput Flow Cytometry Cell-based Assay to Detect Antibodies to N-Methyl-D-aspartate Receptor or Dopamine-2 Receptor in Human Serum
10:19

High-throughput Flow Cytometry Cell-based Assay to Detect Antibodies to N-Methyl-D-aspartate Receptor or Dopamine-2 Receptor in Human Serum

Published on: November 23, 2013

16.8K

Related Experiment Videos

Last Updated: Mar 8, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

7.2K
A Simple Cell-based Immunofluorescence Assay to Detect Autoantibody Against the N-Methyl-D-Aspartate NMDA Receptor in Blood
07:20

A Simple Cell-based Immunofluorescence Assay to Detect Autoantibody Against the N-Methyl-D-Aspartate NMDA Receptor in Blood

Published on: January 9, 2018

10.5K
High-throughput Flow Cytometry Cell-based Assay to Detect Antibodies to N-Methyl-D-aspartate Receptor or Dopamine-2 Receptor in Human Serum
10:19

High-throughput Flow Cytometry Cell-based Assay to Detect Antibodies to N-Methyl-D-aspartate Receptor or Dopamine-2 Receptor in Human Serum

Published on: November 23, 2013

16.8K

Area of Science:

  • Neuroimmunology
  • Infectious Diseases

Background:

  • Herpes simplex virus encephalitis (HSVE) can lead to severe neurological complications and relapses.
  • A subset of HSVE relapses may stem from secondary autoimmune responses, notably anti-NMDAR antibody encephalitis.

Approach:

  • This review examines the literature on the relationship between HSVE and the development of autoimmunity.
  • Investigating potential mechanisms such as molecular mimicry and immune responses to neuronal damage.

Key Points:

  • Autoantibodies, including NMDAR antibodies, are found in cerebrospinal fluid after HSVE, typically weeks post-infection.
  • Evidence increasingly supports a connection between HSVE and subsequent NMDAR encephalitis development.
  • Potential mechanisms involve molecular mimicry or immune reactions to HSV-induced neuronal injury.

Conclusions:

  • HSVE is linked to the development of autoimmune NMDAR encephalitis.
  • Further research is needed to determine if immunotherapy can prevent post-HSVE autoimmunity.