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Platelet microvesicles in health and disease

Imene Melki1, Nicolas Tessandier1, Anne Zufferey1

  • 1a Centre de Recherche du Centre Hospitalier Universitaire de Québec, Faculty of Medicine , Department of Infectious Diseases and Immunity, Université Laval , Quebec City , QC , Canada.

Platelets
|January 20, 2017
PubMed

Insights

Platelet-derived microvesicles (PMVs) are abundant in blood and involved in thrombosis. Altered PMV levels indicate various diseases, suggesting their potential as diagnostic biomarkers.

Area of Science:

  • Cell biology
  • Hematology
  • Biochemistry

Background:

  • Extracellular vesicles, including microvesicles, are increasingly studied for their roles in health and disease.
  • Platelet-derived microvesicles (PMVs) are the most common microvesicles in blood.
  • PMVs carry adhesion molecules and influence coagulation.

Purpose of the Study:

  • To review recent findings on platelet-derived microvesicles (PMVs).
  • To discuss the role of PMVs in physiological and pathological conditions.
  • To explore the potential of PMVs as biomarkers.

Main Methods:

  • Literature review of recent research on PMVs.
  • Analysis of PMV cargo and function.
  • Examination of PMV levels in various disease states.

Main Results:

  • PMVs are abundant and play a role in thrombosis by supporting the coagulation cascade.
  • Circulating PMV levels are altered in conditions like cancer, cardiovascular diseases, and autoimmune disorders.
  • PMVs contain a diverse cargo, including adhesion molecules.

Conclusions:

  • Platelet-derived microvesicles are significant in both normal physiology and disease pathogenesis.
  • Altered levels of PMVs in circulation suggest their utility as potential biomarkers for various diseases.
  • Further research into PMVs can elucidate their complex roles and therapeutic potential.
Keywords:
Diseasehealthmicrovesiclesplatelet microparticles

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