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Nervous Tissue: Myelin

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The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
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Updated: Mar 8, 2026

Preparation and Immunostaining of Myelinating Organotypic Cerebellar Slice Cultures

Preparation and Immunostaining of Myelinating Organotypic Cerebellar Slice Cultures

Published on: March 20, 2019

lnc'edin to Myelin.

Stacey M Glasgow¹, Benjamin Deneen¹

¹Center for Cell and Gene Therapy, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

|January 20, 2017

Summary

This summary is machine-generated.

Long non-coding RNAs (lncRNAs) are crucial for development. This study reveals lncRNA dynamics, function, and mechanisms in oligodendrocyte development and injury.

Keywords:

lncRNA oligodendrocyte

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Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin

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Published on: March 26, 2015

Area of Science:

Neuroscience
Molecular Biology
Genetics

Background:

Long non-coding RNAs (lncRNAs) play significant roles in cellular processes.
Oligodendrocytes are critical for central nervous system function.
Understanding lncRNA involvement in oligodendrocyte development and injury is essential.

Purpose of the Study:

To investigate the expression patterns of lncRNAs during oligodendrocyte development.
To elucidate the functional roles and mechanisms of lncRNAs in oligodendrocyte differentiation.
To examine the impact of injury on lncRNA expression and oligodendrocyte function.

Main Methods:

Bioinformatic analysis of lncRNA expression data.
Experimental validation of lncRNA function in oligodendrocyte precursor cells.
In vivo studies using animal models of central nervous system injury.

Main Results:

Identification of novel lncRNAs associated with oligodendrocyte differentiation.
Demonstration of specific lncRNAs regulating key developmental pathways.
Characterization of altered lncRNA profiles following demyelinating injury.
Evidence for lncRNA-mediated mechanisms in oligodendrocyte repair and regeneration.

Conclusions:

lncRNAs are integral regulators of oligodendrocyte development and homeostasis.
lncRNA dysregulation contributes to pathological processes after CNS injury.
Targeting lncRNAs may offer therapeutic strategies for neurological disorders.