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Updated: Mar 8, 2026

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Tissue-based next generation sequencing: application in a universal healthcare system

Seán O Hynes1, Brendan Pang2,3, Jacqueline A James1,4

  • 1Northern Ireland Molecular Pathology Laboratory, Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland, UK.

British Journal of Cancer
|January 20, 2017
PubMed

Insights

Next-generation sequencing (NGS) advances personalized medicine for solid tumors by tracking genetic mutations. Integrating NGS into universal healthcare settings is feasible despite resource challenges.

Area of Science:

  • Oncology
  • Genomics
  • Personalized Medicine

Background:

  • Cancer therapies are evolving towards personalized medicine, targeting specific genetic mutations in solid tumors.
  • Next-generation sequencing (NGS) is crucial for identifying and tracking multiple driving mutations.
  • A morphomolecular approach combined with NGS offers potential for personalized cancer treatment.

Purpose of the Study:

  • To review the application of NGS in a universal healthcare (UHC) setting.
  • To explore the integration of NGS into diagnostic, clinical trial, and research paradigms.
  • To propose a unified integromic approach for managing complex genomic data.

Main Methods:

  • Review of existing literature on NGS technology and its clinical applications.
  • Analysis of challenges in implementing NGS in routine clinical practice, particularly within UHC systems.
  • Development of strategies for overcoming barriers such as validation, data handling, and reporting.

Main Results:

  • NGS holds significant potential for personalized medicine in solid tumors.
  • Challenges in NGS implementation include data management, reporting, and resource limitations in UHC.
  • A unified integromic approach can streamline the use of NGS data.

Conclusions:

  • The challenges of applying NGS in UHC settings are surmountable.
  • Routine application of NGS is feasible across diagnostic, clinical trial, and research settings.
  • Further development is needed to optimize NGS workflows for UHC environments.

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