Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

4.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
4.0K
Epigenetic Regulation01:46

Epigenetic Regulation

34.1K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
34.1K
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

7.8K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
7.8K
Histone Modification02:32

Histone Modification

16.8K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
16.8K
Histone Modification02:32

Histone Modification

4.7K
4.7K
Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

9.8K
The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
9.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PGS Browser: a public platform for personalized polygenic score analysis and interpretation.

Nature communications·2026
Same author

Genetic architecture of 67 oral diseases and their links to systemic diseases.

HGG advances·2026
Same author

GWAS Meta-analysis Identifies Novel Associated Loci and Points to Causal Tissues in Central Serous Chorioretinopathy.

medRxiv : the preprint server for health sciences·2026
Same author

Altered neurodevelopmental trajectories of brain structure in Tourette syndrome and Chronic Tic Disorders.

medRxiv : the preprint server for health sciences·2026
Same author

Scalable biological-cognitive profiling for Alzheimer's disease in the population.

Brain communications·2026
Same author

Discovering Age- and Sex-Specific Genetic Risk Factors in Sensorineural Hearing Loss: Genome-Wide Evidence from Large-Scale Biobanks.

Journal of the Association for Research in Otolaryngology : JARO·2026

Related Experiment Video

Updated: Mar 8, 2026

Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1
11:19

Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1

Published on: September 26, 2015

8.5K

Epigenetic DNA methylation changes associated with headache chronification: A retrospective case-control study.

Bendik S Winsvold1,2, Priit Palta3,4, Else Eising5

  • 11 FORMI and Department of Neurology, Oslo University Hospital, Oslo, Norway.

Cephalalgia : an International Journal of Headache
|January 21, 2017
PubMed
Summary

This study explored DNA methylation changes linked to headache chronification. Key findings suggest epigenetic alterations in genes like SH2D5 and NPTX2 may play a role in chronic headache development.

Keywords:
Chronic headachecohort studiesepigenetics

More Related Videos

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
13:11

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Published on: July 12, 2012

19.4K
Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
09:42

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Published on: September 7, 2017

10.3K

Related Experiment Videos

Last Updated: Mar 8, 2026

Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1
11:19

Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1

Published on: September 26, 2015

8.5K
Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
13:11

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Published on: July 12, 2012

19.4K
Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
09:42

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Published on: September 7, 2017

10.3K

Area of Science:

  • Epigenetics
  • Neuroscience
  • Genomics

Background:

  • Headache chronification mechanisms remain unclear.
  • Understanding the biological basis of transforming episodic to chronic headache is crucial.

Purpose of the Study:

  • To identify DNA methylation changes associated with headache chronification.
  • To investigate epigenetic alterations in the transition from episodic to chronic headache.

Main Methods:

  • Genome-wide DNA methylation analysis at 485,000 CpG sites.
  • Comparison of methylation levels between female headache patients who transformed and controls with episodic headache.
  • Utilized data from the population-based Norwegian HUNT Study with a 11-year follow-up.

Main Results:

  • No top CpG sites replicated between study stages after correction.
  • Strongest associations in meta-analysis linked CpG sites to SH2D5 and NPTX2 genes.
  • Functional enrichment analysis indicated roles for calcium ion binding and estrogen receptor pathways.

Conclusions:

  • This genome-wide study identified potential epigenetic loci and processes in headache chronification.
  • The findings highlight the role of synaptic plasticity-related genes and pathways.
  • Prospectively collected cohorts are valuable for studying epigenetic mechanisms of disease.