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Radiation absorbed dose estimates for 18F-BPA PET.

Yuzuru Kono1, Hiroaki Kurihara1, Hiroshi Kawamoto2

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Acta Radiologica (Stockholm, Sweden : 1987)
|January 21, 2017
PubMed
Summary

This study found that the PET tracer 18F-BPA has lower radiation doses than 18F-FDG, with adult patients receiving significantly less radiation than pediatric patients during Boron Neutron Capture Therapy (BNCT) assessments.

Keywords:
18F-BPA PETBoron neutron capture therapy (BNCT)effective doseradiation absorbed dose

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Area of Science:

  • Nuclear Medicine
  • Radiation Oncology
  • Radiochemistry

Background:

  • Boron Neutron Capture Therapy (BNCT) is a targeted radiation therapy for cancer.
  • Effective BNCT relies on delivering the boron-10 (10B) isotope to cancer cells.
  • 18F-BPA is a PET tracer used to predict the accumulation of the therapeutic agent 4-borono-phenylalanine conjugated with fructose (BPA-fr).

Purpose of the Study:

  • To determine the biodistribution and dosimetric parameters of the PET tracer 18F-BPA.
  • To compare radiation dose calculations for 18F-BPA with published data for 18F-FDG.

Main Methods:

  • Prospective collection of human biokinetic data from 18F-BPA PET/CT studies.
  • Calculation of internal radiation dose using the OLINDA/EXM 1.1 program based on radioactivity measurements.
  • Comparison of calculated 18F-BPA doses with published 18F-FDG data from ICRP Publication 106.

Main Results:

  • Adult patients exhibited significantly lower absorbed radiation doses compared to pediatric patients (P = 0.003).
  • The mean effective dose for 18F-BPA was 57% lower in adults than in children.
  • Mean effective doses for 18F-BPA were, on average, 25% lower than those reported for 18F-FDG.

Conclusions:

  • Significant differences exist in organ absorbed doses between 18F-BPA and 18F-FDG.
  • 18F-BPA demonstrates a favorable dosimetry profile, with lower mean effective doses compared to 18F-FDG.
  • These findings are crucial for optimizing radiation dosimetry in BNCT planning.