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Acute Calcineurin Inhibitor Nephrotoxicity Secondary to Turmeric Intake: A Case Report.

A Nayeri1, S Wu1, E Adams1

  • 1Department of Medicine, University of California, Los Angeles, California.

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|January 21, 2017
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Summary

Turmeric may interact with tacrolimus (FK-506), a common immunosuppressant. This case highlights a probable food-drug interaction causing acute kidney injury in a liver transplant patient due to high turmeric intake.

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Area of Science:

  • Pharmacology
  • Nephrology
  • Integrative Medicine

Background:

  • Tacrolimus (FK-506) is a vital immunosuppressant post-transplantation.
  • It has known drug-drug and food-drug interactions.
  • Calcineurin inhibitor nephrotoxicity is a significant clinical concern.

Observation:

  • A liver transplant recipient developed acute kidney injury with elevated creatinine.
  • The patient's tacrolimus levels were significantly high despite a stable medication regimen.
  • The patient reported recent high-dose consumption of turmeric.

Findings:

  • This case suggests a probable food-drug interaction between turmeric and tacrolimus.
  • Elevated turmeric intake likely contributed to increased tacrolimus blood levels.
  • Discontinuation of tacrolimus led to improved renal function.

Implications:

  • Clinicians should inquire about herbal supplement use, like turmeric, in patients on tacrolimus.
  • Understanding herb-drug interactions is crucial for managing immunosuppression.
  • This interaction may impact tacrolimus pharmacokinetics and patient outcomes.