Tacrolimus-associated Diffuse Gastrointestinal Ulcerations and Pathergy: A Case Report

Area of Science:

• Immunology
• Transplantation Medicine
• Gastroenterology

Background:

• Tacrolimus is a vital immunosuppressant used in organ transplantation and autoimmune diseases.
• Common side effects include nephrotoxicity, neurotoxicity, infection risk, and anemia.
• Understanding the full spectrum of tacrolimus toxicity is crucial for patient management.

Observation:

• A cardiac transplant recipient presented with an unusual manifestation of tacrolimus toxicity.
• The patient developed diffuse gastrointestinal ulcerations and pathergy.
• These symptoms are not typically associated with tacrolimus adverse effects.

Findings:

• This case report details a rare presentation of tacrolimus-induced gastrointestinal ulcerations and pathergy.
• The findings expand the known side effect profile of tacrolimus.
• This highlights the importance of considering drug toxicity in complex patient presentations.

Implications:

• Clinicians should be aware of rare gastrointestinal manifestations of tacrolimus toxicity.
• Early recognition and management of these unusual side effects can improve patient outcomes.
• Further research may elucidate the mechanisms behind this rare tacrolimus toxicity.