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Pancreas Transplantation After Liver Transplantation: A Case Report
1Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.
Transplantation Proceedings
|January 21, 2017
Summary
This case study details a successful pancreas transplant after liver transplant for uncontrolled diabetes. The patient achieved normal glucose levels without medication, marking a novel approach in transplant medicine.
Area of Science:
- Organ transplantation
- Endocrinology
- Surgical innovation
Background:
- Liver transplantation for end-stage liver disease and hepatocellular carcinoma.
- Development of new-onset, uncontrolled diabetes mellitus post-liver transplant.
- Insulin therapy failure (>100 IU/d) necessitating alternative treatment.
Observation:
- A 53-year-old male patient underwent a pancreas transplant 4 years after liver transplantation.
- A modified cadaveric pancreas transplantation technique was employed.
- Postoperative follow-up included endoscopic biopsy, confirming no thrombosis or rejection.
Findings:
- Successful pancreas transplantation after prior liver transplantation.
- Patient achieved normal glucose levels without need for diabetic medication at 6 months.
- Demonstrated feasibility of pancreas after liver transplant for refractory diabetes.
Implications:
- Establishes a precedent for pancreas transplantation following liver transplantation.
- Offers a potential solution for managing new-onset diabetes post-liver transplant.
- Highlights the importance of considering combined or sequential transplants for complex cases.
