Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

615
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
615
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

616
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
616
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

472
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
472
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

534
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
534
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

285
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
285
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

300
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
300

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differences in responses to TC-81 among various arteries in dogs.

Journal of cardiovascular pharmacology·1992
Same author

Differential scanning calorimetric studies on bovine serum albumin: III. Effect of sodium dodecyl sulphate.

International journal of biological macromolecules·1992
Same author

Relationship between tissue content of TC-81 and relaxation of rat aorta.

European journal of pharmacology·1992
Same author

[The positive rate of hepatitis C virus antibody detected by the second generation method in pregnant women and influence of pregnancy and delivery on HCV infection].

Nihon Sanka Fujinka Gakkai zasshi·1992
Same author

Selective reactivities of isocyanates towards DNA bases and genotoxicity of methylcarbamoylation of DNA.

Mutation research·1992
Same author

Molecular involvement of the pvt-1 locus in a gamma/delta T-cell leukemia bearing a variant t(8;14)(q24;q11) translocation.

Molecular and cellular biology·1992

Related Experiment Video

Updated: Mar 8, 2026

A Modified Surgical Technique for Kidney Transplantation in Mice
10:38

A Modified Surgical Technique for Kidney Transplantation in Mice

Published on: July 22, 2022

7.3K

Effect of Gender Differences on Transplant Kidney Function.

T Yoneda1, Y Iemura1, K Onishi1

  • 1Department of Urology, Nara Medical University, Nara, Japan.

Transplantation Proceedings
|January 21, 2017
PubMed
Summary
This summary is machine-generated.

Sex differences impact kidney transplant outcomes. Male donors to female recipients showed better short-term kidney function than female donors to male recipients, indicating recipient sex is a key factor.

More Related Videos

Heterotopic Renal Autotransplantation in a Porcine Model: A Step-by-Step Protocol
11:47

Heterotopic Renal Autotransplantation in a Porcine Model: A Step-by-Step Protocol

Published on: February 21, 2016

12.6K
Murine Kidney Transplant Technique
08:58

Murine Kidney Transplant Technique

Published on: October 20, 2015

17.5K

Related Experiment Videos

Last Updated: Mar 8, 2026

A Modified Surgical Technique for Kidney Transplantation in Mice
10:38

A Modified Surgical Technique for Kidney Transplantation in Mice

Published on: July 22, 2022

7.3K
Heterotopic Renal Autotransplantation in a Porcine Model: A Step-by-Step Protocol
11:47

Heterotopic Renal Autotransplantation in a Porcine Model: A Step-by-Step Protocol

Published on: February 21, 2016

12.6K
Murine Kidney Transplant Technique
08:58

Murine Kidney Transplant Technique

Published on: October 20, 2015

17.5K

Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Urology

Background:

  • Sex-based biological differences, including hormonal and immunological variations, may influence transplant kidney function.
  • Previous research suggests potential disparities in outcomes based on sex, necessitating further investigation.

Purpose of the Study:

  • To investigate the impact of sex-mismatched kidney transplantation on graft function.
  • To compare short-term transplant kidney function between male-to-female and female-to-male transplants.

Main Methods:

  • Retrospective analysis of 47 kidney transplant recipients with sex-mismatched donors between 2000 and 2015.
  • Exclusion of cadaveric donors and parent-child pairs.
  • Comparison of transplant kidney function metrics (creatinine, eGFR) between male-to-female (M→F) and female-to-male (F→M) groups.

Main Results:

  • The female-to-male (F→M) group exhibited higher nadir creatinine levels (1.09 mg/dL) compared to the male-to-female (M→F) group (0.76 mg/dL).
  • Estimated glomerular filtration rate (eGFR) was significantly higher in the M→F group (66.6 mL/min/1.73 m²) versus the F→M group (50.1 mL/min/1.73 m²).
  • Recipient sex was identified as a significant prognostic factor for eGFR post-renal transplantation.

Conclusions:

  • Male-to-female kidney transplants demonstrate superior short-term graft function compared to female-to-male transplants.
  • Recipient sex is a critical determinant of early graft performance after kidney transplantation.